RNA complementary to herpes simplex virus type 1 ICP0 gene demonstrated in neurons of human trigeminal ganglia
RNA complementary to herpes simplex virus type 1 ICP0 gene demonstrated in neurons of human trigeminal ganglia
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在人三叉神经节神经元中证实与 1 型单纯疱疹病毒 ICP0 基因互补的 RNA
DOI：
10.1128/jvi.62.5.1832-1835.1988
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发表时间：
1988
影响因子：
5.4
通讯作者：
T. Araullo
中科院分区：
文献类型：
--
作者：
Y. Gordon;B. Johnson;E. Romanowski;T. Araullo
最近对小鼠的研究表明，在潜伏感染的神经节中，大量的RNA转录本与疱疹α基因ICP0互补（反义）。我们调查了三叉神经节未选择的情况。制备了2.7千碱基单纯性疱疹病毒1型（HSV-1） ICP0链特异性RNA探针，并在有效感染细胞中检测其意义。尽管原位杂交显示46%的神经节神经元核中存在ICP0反义RNA转录物，但在任何神经节中均未发现ICP0信使RNA。我们得出结论，HSV-1反义ICP0 RNA在人类神经节潜伏期存在。
Recent studies with mice have demonstrated abundant RNA transcripts which are complementary (antisense) to the herpes alpha gene ICP0 in latently infected ganglia. We investigated the situation in unselected human trigeminal ganglia. Strand-specific 2.7-kilobase herpes simplex virus type 1 (HSV-1) ICP0 RNA probes were prepared, and their sense was determined in productively infected cells. Although in situ hybridization demonstrated ICP0 antisense RNA transcripts in the nuclei of neurons in 46% of the ganglia, ICP0 messenger RNA was not found in any of the ganglia. We conclude that HSV-1 antisense ICP0 RNA is present in humans during ganglionic latency.
影响因子：
56.9
作者：
STEVENS, JG;WAGNER, EK;FELDMAN, LT
通讯作者：
FELDMAN, LT
通过原位杂交在急性和潜伏感染期间将单纯疱疹病毒定位在小鼠中枢神经系统的三叉神经和嗅觉系统中。
DOI：
--
发表时间：
1984
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Stroop,WG;Rock,DL;Fraser,NW
通讯作者：
Fraser,NW