High level of hepcidin mRNA expression is associated with high production of immune factors in Tibetan pigs
High level of hepcidin mRNA expression is associated with high production of immune factors in Tibetan pigs
复制标题
藏猪铁调素 mRNA 的高水平表达与免疫因子的高产生有关
DOI：
10.1016/j.livsci.2014.11.008
复制
发表时间：
2015
影响因子：
1.8
通讯作者：
Du, Hua-hua
中科院分区：
文献类型：
--
作者：
Gao, Yan-hua;Liu, Dan;Wang, Yi-zhen;Du, Hua-hua
Hepcidin, an antimicrobial peptide, is considered to be a key homeostatic regulator of iron metabolism. Tibetan pigs are a Chinese indigenous plateau breed with strong disease resistance. It is therefore of interest to look for porcine hepcidin (pHepc) gene expression in Tibetan pigs in order to clarify the involvement of pHepc in interaction of host defenses and iron homeostasis. In this study, the mRNA expressions of pHepc and the immune response-associated factors were determined by real-time PCR in 30-day-old Tibetan pigs and Landrace pigs were chosen as control. The results showed that the expression of pHepc mRNA in most tissues were higher in Tibetan pigs than those of Landrace pigs, which corresponded to the higher serum iron concentration in Tibetan pigs. In addition, compared to Landrace pigs, higher levels of pro-inflammatory cytokines (TNF-α, IL-1α, IL-1β and IFN-γ), pattern recognition receptors (TLR-2, TLR-4, NOD-1 and NOD-2) and chemokines (MCP-1 and IL-8) were detected in Tibetan pigs, which suggested that Tibetan pigs have a strong immunity. The high expression of pHepc may affect the production of immune factors by regulating iron homeostasis, which may partly explain the strong disease resistance of Tibetan pigs.
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DOI：
--
发表时间：
1986
期刊：
--
影响因子：
--
作者：
Z. Zhang;B. Li;X. Chen;Zg Zhang
通讯作者：
Z. Zhang;B. Li;X. Chen;Zg Zhang
DOI：
--
发表时间：
1985
期刊：
--
影响因子：
--
作者：
Peilieu Cheng
通讯作者：
Peilieu Cheng
DOI：
10.1073/pnas.97.16.8856
发表时间：
2000-08-01
影响因子：
11.1
作者：
Hancock, REW;Scott, MG
通讯作者：
Scott, MG
影响因子：
3.3
作者：
J. Lippolis
通讯作者：
J. Lippolis
影响因子：
2.9
作者：
Douglas, SE;Gallant, JW;Tsoi, SCM
通讯作者：
Tsoi, SCM