R-form lipopolysaccharides (LPS) of Gram-negative bacteria as possible vaccine antigens.
R-form lipopolysaccharides (LPS) of Gram-negative bacteria as possible vaccine antigens.
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革兰氏阴性菌的 R 型脂多糖 (LPS) 作为可能的疫苗抗原。
DOI：
10.1111/j.1574-695x.1997.tb01039.x
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发表时间：
1997
影响因子：
--
通讯作者：
C. Lugowski
中科院分区：
文献类型：
--
作者：
E. S. Stanislavsky;T. Makarenko;E. V. Kholodkova;C. Lugowski
铜绿假单胞菌、沙门氏菌、大肠埃希菌和志贺氏菌。研究了结果表明，铜绿假单胞菌R突变株与LPS核心脂质A区不同结构之间存在抗原关系，E.大肠杆菌、志贺氏菌和铜绿假单胞菌R-LPS对S.微球Re-LPS。用R-LPS制备的疫苗被证明是有效的主动免疫小鼠对抗铜绿假单胞菌感染的制剂。根据免疫方案，疫苗在小鼠中刺激40-100%的保护。
The antigenic and immunogenic properties of R-form lipopolysaccharides (LPS) of Pseudomonas aeruginosa, Salmonella spp., Escherichia coli and Shigella spp. were studied. The results showed the presence of antigenic relationships among P. aeruginosa R mutants with different structures of the LPS core lipid A region and also among E. coli, Shigella and P. aeruginosa R-LPS, but not with S. minnesota Re-LPS. Vaccines prepared with R-LPS proved to be effective preparations for the active immunization of mice against P. aeruginosa infection. The vaccine stimulated 40-100% protection in mice depending upon the scheme of immunization.
与细菌脂多糖的核心和脂质 A 区域反应的单克隆抗体的特异性和交叉反应性。
DOI：
10.1093/infdis/159.2.168
发表时间：
1989
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Pollack,M;Chia,JK;Koles,NL;Miller,M;Guelde,G
通讯作者：
Guelde,G