Parotid gland function after radiotherapy: the combined michigan and utrecht experience.
Parotid gland function after radiotherapy: the combined michigan and utrecht experience.
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DOI：
10.1016/j.ijrobp.2009.07.1708
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发表时间：
2010-10-01
影响因子：
7
通讯作者：
Terhaard, Chris H. J.
中科院分区：
文献类型：
--
作者：
Dijkema, Tim;Raaijmakers, Cornelis P. J.;Ten Haken, Randall K.;Roesink, Judith M.;Braam, Petra M.;Houweling, Anette C.;Moerland, Marinus A.;Eisbruch, Avraham;Terhaard, Chris H. J.
分析密歇根大学和乌得勒支大学医学中心关于头颈部（HN）癌放疗（RT）后一年腮腺正常组织并发症概率（NTCP）的综合和更新结果。222例前瞻性分析的各种HN恶性肿瘤患者接受常规和调强RT治疗。在两个中心使用Lashley杯在RT前和RT后一年测量刺激的个体腮腺流速。流量比<治疗前的25%被定义为并发症。将数据拟合至Lyman-Kutcher-Burman（LKB）模型。RT后一年，共有384个腮腺（密歇根州：157个;乌得勒支：227个）可用于分析。基于平均剂量的联合NTCP分析得出TD 50（导致50%并发症概率的均匀剂量）为39.9戈伊，m（曲线陡度）为0.40。所得NTCP曲线与合并的临床数据具有良好的定性一致性。平均剂量25-30戈伊与17-26%的NTCP相关。根据平均剂量给出了放疗后一年腮腺功能的NTCP曲线。未观察到阈值剂量，TD 50等于40戈伊。
To analyse the combined and updated results from the University of Michigan and University Medical Center Utrecht on normal tissue complication probability (NTCP) of the parotid gland one year after radiotherapy (RT) for head and neck (HN) cancer. 222 prospectively analyzed patients with various HN malignancies were treated with conventional and intensity-modulated RT. Stimulated individual parotid gland flow rates were measured before RT and one year after RT using Lashley cups at both centers. A flow ratio <25% of pre-treatment was defined as a complication. The data were fitted to the Lyman-Kutcher-Burman (LKB) model. A total of 384 parotid glands (Michigan: 157; Utrecht: 227 glands) was available for analysis one year after RT. Combined NTCP analysis based on mean dose resulted in TD50 (uniform dose leading to 50% complication probability) of 39.9 Gy and m (steepness of the curve) of 0.40. The resulting NTCP curve had good qualitative agreement with the combined clinical data. Mean doses 25-30 Gy were associated with 17-26% NTCP. A definite NTCP curve for parotid gland function one year after RT is presented based on mean dose. No threshold dose was observed and TD50 was equal to 40 Gy.
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DOI：
10.1016/s0360-3016(01)01717-5
发表时间：
2001-11-15
影响因子：
7
作者：
Roesink, JM;Moerland, MA;Terhaard, CHJ
通讯作者：
Terhaard, CHJ
DOI：
10.1016/0360-3016(94)90104-x
发表时间：
1994-03-01
影响因子：
7
作者：
BJORDAL, K;KAASA, S;MASTEKAASA, A
通讯作者：
MASTEKAASA, A
DOI：
10.1016/j.ijrobp.2004.12.076
发表时间：
2005-07-15
影响因子：
7
作者：
Blanco, AI;Chao, KSC;Deasy, JO
通讯作者：
Deasy, JO
影响因子：
3.5
作者：
Eisbruch, A;Ship, JA;Ten Haken, RK
通讯作者：
Ten Haken, RK
影响因子：
5.7
作者：
Tenhunen, Mikko;Collan, Juhani;Saarilahti, Kauko
通讯作者：
Saarilahti, Kauko