Pervasive but Neglected: A Perspective on COVID-19-Associated Pulmonary Mold Infections Among Mechanically Ventilated COVID-19 Patients.
Pervasive but Neglected: A Perspective on COVID-19-Associated Pulmonary Mold Infections Among Mechanically Ventilated COVID-19 Patients.
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无处不在但被忽视：机械通风的Covid-19患者中与19例相关的肺部霉菌感染的观点。
DOI：
10.3389/fmed.2021.649675
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发表时间：
2021
影响因子：
3.9
通讯作者：
Hedayati MT
中科院分区：
文献类型：
--
作者：
Ghazanfari M;Arastehfar A;Davoodi L;Yazdani Charati J;Moazeni M;Abastabar M;Haghani I;Mirzakhani R;Mayahi S;Fang W;Liao W;Nguyen MH;Perlin DS;Hoenigl M;Pan W;Hedayati MT
Background: Recent studies from multiple countries have shown a high prevalence of coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) among severely ill patients. Despite providing valuable insight into the clinical management of CAPA, large-scale prospective studies are limited. Here, we report on one of the largest multicenter epidemiological studies to explore the clinical features and prevalence of COVID-19-associated pulmonary mold infections (CAPMIs) among mechanically ventilated patients. Methods: Bronchoalveolar lavage (BAL) and serum samples were collected for culture, galactomannan (GM), and β-D-glucan (BDG) testing. Patients were classified as probable CAPMI based on the presence of host factors, radiological findings, and mycological criteria. Results: During the study period, 302 COVID-19 patients were admitted to intensive care units (ICUs), among whom 105 were mechanically ventilated for ≥4 days. Probable CAPMI was observed among 38% of patients (40/105), among whom BAL culture of 29 patients turned positive for molds, while galactomannan testing on BAL (GM index ≥1) and serum (GM index >0.5) samples were positive for 60% (24/40) and 37.5% (15/39) of patients, respectively. Aspergillus (22/29; 75.8%) and Fusarium (6/29; 20.6%) constituted 96.5% of the molds isolated. Diaporthe foeniculina was isolated from a COVID-19 patient. None of the patients who presented with CAPMI were treated with antifungal drugs. Conclusion: Despite being prevalent, the absence of appropriate antifungal treatment highlights that CAPMI is a neglected complication among mechanically ventilated COVID-19 patients admitted to ICUs. CAPMI can be caused by species other than Aspergillus.
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影响因子：
2.6
作者：
Rakita, Robert M.;O'Brien, Kevin D.;Bourassa, Lori
通讯作者：
Bourassa, Lori
影响因子：
2.2
作者：
Mattei, Antonella S.;Severo, Cecilia B.;Severo, Luiz Carlos
通讯作者：
Severo, Luiz Carlos
影响因子：
11.8
作者：
Donnelly, J. Peter;Chen, Sharon C.;Pappas, Peter G.
通讯作者：
Pappas, Peter G.
DOI：
10.1016/s1473-3099(20)30847-1
发表时间：
2021-06
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Koehler P;Bassetti M;Chakrabarti A;Chen SCA;Colombo AL;Hoenigl M;Klimko N;Lass-Flörl C;Oladele RO;Vinh DC;Zhu LP;Böll B;Brüggemann R;Gangneux JP;Perfect JR;Patterson TF;Persigehl T;Meis JF;Ostrosky-Zeichner L;White PL;Verweij PE;Cornely OA;European Confederation of Medical Mycology;International Society for Human Animal Mycology;Asia Fungal Working Group;INFOCUS LATAM/ISHAM Working Group;ISHAM Pan Africa Mycology Working Group;European Society for Clinical Microbiology;Infectious Diseases Fungal Infection Study Group;ESCMID Study Group for Infections in Critically Ill Patients;Interregional Association of Clinical Microbiology and Antimicrobial Chemotherapy;Medical Mycology Society of Nigeria;Medical Mycology Society of China Medicine Education Association;Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology;Association of Medical Microbiology;Infectious Disease Canada
通讯作者：
Infectious Disease Canada
影响因子：
4.9
作者：
Koehler, Philipp;Cornely, Oliver A.;Shimabukuro-Vornhagen, Alexander
通讯作者：
Shimabukuro-Vornhagen, Alexander