Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels.
Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels.
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DOI：
10.1085/jgp.201210849
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Horrigan FT
中科院分区：
文献类型：
--
作者：
Horrigan FT
大电导钙和电压依赖性BK钾通道（又名BKCa、MaxiK、Slo1、KCa1.1和KCNMA1）在全身各种组织中表达，并被细胞内Ca2+和膜去极化激活。由于这些特性，BK通道参与多种生理过程，从神经元和分泌细胞的电兴奋性、平滑肌张力的调节到听觉毛细胞的调节。对电压和Ca2+的响应允许BK通道整合电和钙信号，这是其生理作用的核心。了解BK和其他多模态通道如何受到不同刺激的调节和整合，不仅在生理学上很重要，而且与构象耦合的主题有关。作为电压和配体依赖的通道，BK通道包含电压传感器和配体结合域，以及调节K+通过孔的流动的门。一个域与另一个域的构象变化耦合为将电压和配体结合转化为通道打开提供了基础，因此，与栅极和传感器的功能特性一起，定义了通道的信号转导特性。这一观点的目的是概述BK通道中功能域之间构象耦合的作用和分子基础，并概述一些有待回答的问题。
Large conductance calcium- and voltage-dependent BK potassium channels (aka BKCa, MaxiK, Slo1, KCa1.1, and KCNMA1) are expressed in a wide variety of tissues throughout the body and are activated by both intracellular Ca2+ and membrane depolarization. Owing to these properties, BK channels participate in diverse physiological processes from electrical excitability in neurons and secretory cells, and regulation of smooth muscle tone to tuning of auditory hair cells. The response to voltage and Ca2+ allows BK channels to integrate electrical and calcium signaling, which is central to their physiological role. Understanding how BK and other multimodal channels are regulated by and integrate diverse stimuli is not only physiologically important but also relevant to the topic of conformational coupling. As a voltage- and ligand-dependent channel, BK channels contain both voltage-sensor and ligand-binding domains as well as a gate to regulate the flow of K+ through the pore. Coupling of conformational changes in one domain to another provides the basis for transducing voltage and ligand binding into channel opening and, therefore, defines, together with the functional properties of the gate and sensors, the signal transduction properties of the channel. The goal of this perspective is to provide an overview on the role and molecular basis of conformational coupling between functional domains in BK channels and outline some of the questions that remain to be answered.
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影响因子：
64.8
作者：
Long, Stephen B.;Tao, Xiao;MacKinnon, Roderick
通讯作者：
MacKinnon, Roderick
DOI：
10.1085/jgp.200609521
发表时间：
2006-10
期刊：
The Journal of general physiology
影响因子：
--
作者：
Li W;Aldrich RW
通讯作者：
Aldrich RW
MG2+增强了BK通道中的电压传感器/门耦合。
影响因子：
3.8
作者：
Horrigan, Frank T.;Ma, Zhongming
通讯作者：
Ma, Zhongming
影响因子：
4.8
作者：
Brenner, R;Jegla, TJ;Aldrich, RW
通讯作者：
Aldrich, RW
DOI：
10.1073/pnas.1003609107
发表时间：
2010-11-02
影响因子：
11.1
作者：
Chowdhury, Sandipan;Chanda, Baron
通讯作者：
Chanda, Baron