Isoflurane-Induced Burst Suppression Is a Thalamus-Modulated, Focal-Onset Rhythm With Persistent Local Asynchrony and Variable Propagation Patterns in Rats.
Isoflurane-Induced Burst Suppression Is a Thalamus-Modulated, Focal-Onset Rhythm With Persistent Local Asynchrony and Variable Propagation Patterns in Rats.
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DOI：
10.3389/fnsys.2020.599781
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发表时间：
2020
影响因子：
3
通讯作者：
Ma H
中科院分区：
文献类型：
--
作者：
Ming Q;Liou JY;Yang F;Li J;Chu C;Zhou Q;Wu D;Xu S;Luo P;Liang J;Li D;Pryor KO;Lin W;Schwartz TH;Ma H
背景：吸入麻醉诱导的爆发抑制（BS）被经典地认为是一种双侧同步节律。然而，在理论研究中已经预测到局部复发，并在已有局灶性病理的患者中报告。方法：应用高速宽场钙离子显像技术研究异氟醚诱导的大鼠BS的时空动态变化。结果：我们发现异氟醚诱导的BS不是一个全球同步的节奏。在新皮层中，神经活动首先出现在一个空间转移的、局部化的焦点上。随后在整个皮层的传播是迅速的，通常在100毫秒内，给人以全球同步的表面相似性。神经活动在爆发期间保持局部异步，形成复杂的经常性传播波。尽管传播的变异性，空间序列的突发传播在很大程度上保留半球之间，和神经活动高度相关的同伦区域之间。通过使用单侧丘脑河豚毒素注射证明了丘脑在皮质爆发启动中的关键作用。结论：麻醉剂诱导的BS是一种全球大脑同步状态的经典印象是不准确的。爆发是一系列由丘脑投射促进的局部皮层事件，这些事件以快速、双侧异步传播波的形式展开。
Background: Inhalational anesthetic-induced burst suppression (BS) is classically considered a bilaterally synchronous rhythm. However, local asynchrony has been predicted in theoretical studies and reported in patients with pre-existing focal pathology. Method: We used high-speed widefield calcium imaging to study the spatiotemporal dynamics of isoflurane-induced BS in rats. Results: We found that isoflurane-induced BS is not a globally synchronous rhythm. In the neocortex, neural activity first emerged in a spatially shifting, variably localized focus. Subsequent propagation across the whole cortex was rapid, typically within <100 milliseconds, giving the superficial resemblance to global synchrony. Neural activity remained locally asynchronous during the bursts, forming complex recurrent propagating waves. Despite propagation variability, spatial sequences of burst propagation were largely preserved between the hemispheres, and neural activity was highly correlated between the homotopic areas. The critical role of the thalamus in cortical burst initiation was demonstrated by using unilateral thalamic tetrodotoxin injection. Conclusion: The classical impression that anesthetics-induced BS is a state of global brain synchrony is inaccurate. Bursts are a series of shifting local cortical events facilitated by thalamic projection that unfold as rapid, bilaterally asynchronous propagating waves.
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DOI：
10.1056/nejmra0808281
发表时间：
2010-12-30
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brown EN;Lydic R;Schiff ND
通讯作者：
Schiff ND
影响因子：
5.7
作者：
Fritz BA;Kalarickal PL;Maybrier HR;Muench MR;Dearth D;Chen Y;Escallier KE;Ben Abdallah A;Lin N;Avidan MS
通讯作者：
Avidan MS
影响因子：
2.5
作者：
Christophe, E;Doerflinger, N;Audinat, E
通讯作者：
Audinat, E
影响因子：
7.7
作者：
Aedo-Jury, Felipe;Schwalm, Miriam;Stroh, Albrecht
通讯作者：
Stroh, Albrecht
DOI：
10.1016/s0987-7053(97)85100-3
发表时间：
1996-01-01
影响因子：
3
作者：
An, DS;Straumann, D;Wieser, HG
通讯作者：
Wieser, HG