MicroRNA in TLR signaling and endotoxin tolerance.
MicroRNA in TLR signaling and endotoxin tolerance.
复制标题
TLR信号传导和内毒素耐受性中的microRNA。
DOI：
10.1038/cmi.2011.26
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发表时间：
2011-09
影响因子：
24.1
通讯作者：
中科院分区：
文献类型：
--
作者：
天然免疫细胞中的toll样受体（TLRs）是微生物成分的主要细胞传感器。TLR激活导致促炎介质的产生，因此TLR信号必须通过各种机制适当调节以维持体内平衡。tlr4 -配体脂多糖（LPS）诱导的耐受性或交叉耐受性是其中一种机制，在先天免疫中起重要作用。耐受性是由microRNA miR-146a的活性建立和维持的，已知miR-146a靶向髓样分化因子88 （MyD88）信号通路的关键元件，包括IL-1受体相关激酶（IRAK1）、IRAK2和肿瘤坏死因子（TNF）受体相关因子6 （TRAF6）。在这篇综述中，我们全面研究了TLR信号在先天免疫中的作用，特别关注lps诱导的耐受性。本文讨论了TLR配体诱导的microrna（包括miR-146a、miR-155和miR-132）在调节炎症介质中的功能及其对免疫系统和人类疾病的影响。这些microrna的调节可能影响TLR通路的激活，并有助于开发抗炎症性疾病的治疗方法。
Toll-like receptors (TLRs) in innate immune cells are the prime cellular sensors for microbial components. TLR activation leads to the production of proinflammatory mediators and thus TLR signaling must be properly regulated by various mechanisms to maintain homeostasis. TLR4-ligand lipopolysaccharide (LPS)-induced tolerance or cross-tolerance is one such mechanism, and it plays an important role in innate immunity. Tolerance is established and sustained by the activity of the microRNA miR-146a, which is known to target key elements of the myeloid differentiation factor 88 (MyD88) signaling pathway, including IL-1 receptor-associated kinase (IRAK1), IRAK2 and tumor-necrosis factor (TNF) receptor-associated factor 6 (TRAF6). In this review, we comprehensively examine the TLR signaling involved in innate immunity, with special focus on LPS-induced tolerance. The function of TLR ligand-induced microRNAs, including miR-146a, miR-155 and miR-132, in regulating inflammatory mediators, and their impact on the immune system and human diseases, are discussed. Modulation of these microRNAs may affect TLR pathway activation and help to develop therapeutics against inflammatory diseases.
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影响因子：
10.5
作者：
Babiarz, Joshua E.;Ruby, J. Graham;Blelloch, Robert
通讯作者：
Blelloch, Robert
DOI：
10.1084/jem.86.1.29
发表时间：
1947-06-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Beeson PB;Technical Assistance of Elizabeth Roberts
通讯作者：
Technical Assistance of Elizabeth Roberts
影响因子：
30.5
作者：
Boone, DL;Turer, EE;Ma, A
通讯作者：
Ma, A
影响因子：
8
作者：
Anastasiadou, E.;Boccellato, F.;Trivedi, P.
通讯作者：
Trivedi, P.
影响因子：
8.6
作者：
Bhanji, Rahima A.;Eystathioy, Theophany;Fritzler, Marvin J.
通讯作者：
Fritzler, Marvin J.