Intraindividual variation in core microbiota in peri-implantitis and periodontitis.
Intraindividual variation in core microbiota in peri-implantitis and periodontitis.
复制标题
DOI：
10.1038/srep06602
复制
发表时间：
2014-10-13
影响因子：
4.6
通讯作者：
Nakagawa I
中科院分区：
文献类型：
--
作者：
Maruyama N;Maruyama F;Takeuchi Y;Aikawa C;Izumi Y;Nakagawa I
口腔微生物区系随口腔各部分的不同而变化很大，甚至在同一个口腔内也是如此。然而，与种植周炎和牙周炎相关的微生物区系被认为是相同的。为了提高我们对复杂口腔微生物区系不同群落的了解，我们比较了20名患有这两种疾病的种植体周围炎和牙周炎患者的微生物特征。虽然种植体周围炎的临床症状与牙周炎相似，但两种疾病的核心微生物区系不同。相关分析揭示了特定的微生物共生模式，并发现一些物种以疾病特异性的方式与临床参数相关联。种植周炎中黑色普氏杆菌的比例显著高于牙周炎，而消化链球菌所占比例明显高于牙周炎。口腔脱硫菌在牙周炎组明显高于种植体周围炎组。种植体周围炎的严重程度也与物种有关，包括未培养的密螺旋体。与4个临床参数相关。这些结果表明，种植周炎和牙周炎都是由不同病原体引起的多菌感染。我们的研究为种植周炎和牙周炎之间生态上不同的细菌群落提供了一个框架，这将有助于进一步研究复杂的微生物区系和口腔多菌疾病的致病机制。
The oral microbiota change dramatically with each part of the oral cavity, even within the same mouth. Nevertheless, the microbiota associated with peri-implantitis and periodontitis have been considered the same. To improve our knowledge of the different communities of complex oral microbiota, we compared the microbial features between peri-implantitis and periodontitis in 20 patients with both diseases. Although the clinical symptoms of peri-implantitis were similar to those of periodontitis, the core microbiota of the diseases differed. Correlation analysis revealed the specific microbial co-occurrence patterns and found some of the species were associated with the clinical parameters in a disease-specific manner. The proportion of Prevotella nigrescens was significantly higher in peri-implantitis than in periodontitis, while the proportions of Peptostreptococcaceae sp. and Desulfomicrobium orale were significantly higher in periodontitis than in peri-implantitis. The severity of the peri-implantitis was also species-associated, including with an uncultured Treponema sp. that correlated to 4 clinical parameters. These results indicate that peri-implantitis and periodontitis are both polymicrobial infections with different causative pathogens. Our study provides a framework for the ecologically different bacterial communities between peri-implantitis and periodontitis, and it will be useful for further studies to understand the complex microbiota and pathogenic mechanisms of oral polymicrobial diseases.
登录
查看更多内容
影响因子：
4.4
作者：
Hsiao WW;Li KL;Liu Z;Jones C;Fraser-Liggett CM;Fouad AF
通讯作者：
Fouad AF
影响因子：
4.3
作者：
Faust K;Sathirapongsasuti JF;Izard J;Segata N;Gevers D;Raes J;Huttenhower C
通讯作者：
Huttenhower C
影响因子：
14.9
作者：
Cole JR;Wang Q;Cardenas E;Fish J;Chai B;Farris RJ;Kulam-Syed-Mohideen AS;McGarrell DM;Marsh T;Garrity GM;Tiedje JM
通讯作者：
Tiedje JM
影响因子：
11
作者：
Barberan, Albert;Bates, Scott T.;Fierer, Noah
通讯作者：
Fierer, Noah
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y