Size-tunable synthesis of stable superparamagnetic iron oxide nanoparticles for potential biomedical applications.
Size-tunable synthesis of stable superparamagnetic iron oxide nanoparticles for potential biomedical applications.
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DOI：
10.1002/jbm.a.32489
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发表时间：
2010-03-15
影响因子：
4.9
通讯作者：
Yang, Victor C.
中科院分区：
文献类型：
--
作者：
Yu, Faquan;Yang, Victor C.
葡聚糖涂层的超顺磁性纳米颗粒（MNP）具有广泛的生物医学应用。超顺磁性行为、专门调节的尺寸和光滑的形态是基本上所有这些应用的关键要求。本文提出了一种创新的双涂层策略，可实现 MNP 尺寸控制的合成。首先合成了小型单晶氧化铁纳米颗粒（MION），它是超顺磁性的来源。然后将这些 MION 在含有生物相容性葡聚糖聚合物的醋酸盐缓冲液中进行处理。在这样的环境下，胶体MION会被乙酸根离子快速团聚，形成的MION聚结体同时被葡聚糖包覆而稳定。通过调节 MION 或葡聚糖浓度以及热孵育时间，可以轻松控制这些首次形成的纳米颗粒（称为 1st-NP）的尺寸。进一步应用第二个葡聚糖包被步骤以平滑第一个纳米颗粒以获得最终产品（称为第二个纳米颗粒）。由于额外的涂层壳，2nd-NPs 表现出强大的储存稳定性。结果成功证实了这种方法的合理性，因为这些 MNP 不仅表现出平滑的轮廓和狭窄的尺寸分布，而且还表现出基本的超顺磁性行为和显着延长的储存稳定性。
Dextran-coated superparamagnetic nanoparticles (MNPs) have widespread biomedical applications. The superparamagnetic behavior, specifically regulated size, and smooth morphology are crucial requirements for essentially all of these applications. Presented herein is an innovative double-coating strategy that would allow for a size-controlled synthesis of MNPs. Small monocrystalline iron oxide nanoparticles (MIONs) were first synthesized, which served as the source of superparamagnetic properties. These MIONs were then treated in an acetate buffer containing biocompatible dextran polymer. Under such an environment, the colloidal MIONs would be quickly agglomerated by the acetate ions, and the formed coalescent body of MION would then be stabilized simultaneously by coating with dextran. By regulating the MION or dextran concentration as well as the thermal incubation time, the sizes of these first formed nanoparticles (termed 1st-NPs) could be readily controlled. A second dextran coating step was further applied to smoothen the 1st-NPs in attaining a final product (termed 2nd-NPs). The 2nd-NPs exhibited robustly storage stability due to the additional coating shell. Results successfully confirmed the plausibility of this approach, as these MNPs displayed not only a smooth outline and a narrow size distribution, but also the essential superparamagnetic behavior and a significantly prolonged stability upon storage.
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影响因子：
9.9
作者：
Fauconnier, N;Pons, JN;Bee, A
通讯作者：
Bee, A
影响因子：
3.7
作者：
Cheng, JJ;Teply, BA;Langer, RS
通讯作者：
Langer, RS
影响因子：
64.8
作者：
HINGSTON, FJ;ATKINSON, RJ;QUIRK, JP
通讯作者：
QUIRK, JP
DOI：
10.1080/10826079608005537
发表时间：
1996-01-01
影响因子：
1.3
作者：
Fauconnier, N;Bee, A;Dardoize, F
通讯作者：
Dardoize, F
影响因子：
1.8
作者：
Campos, AFC;Tourinho, FA;Depeyrot, J
通讯作者：
Depeyrot, J