Expression levels of insulin-like growth factors and receptors in hepatocellular carcinoma: a retrospective study.
Expression levels of insulin-like growth factors and receptors in hepatocellular carcinoma: a retrospective study.
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DOI：
10.1186/1477-7819-12-231
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发表时间：
2014-07-22
影响因子：
3.2
通讯作者：
Von Mehren M
中科院分区：
文献类型：
--
作者：
Chun YS;Huang M;Rink L;Von Mehren M
胰岛素样生长因子（IGF）途径与肝细胞癌（HCC）的发病机制有关，并可能在非酒精性脂肪性肝病（NAFLD）中起重要作用。本研究的目的是确定IGFs和受体在nafld相关HCC中的表达水平。组织微阵列是由接受肝切除术的HCC患者构建的。使用IGF配体和受体抗体进行免疫组化。免疫染色结果由不了解临床资料的病理学家评分。在27例HCC患者中，最常见的基础肝脏疾病包括NAFLD、丙型肝炎和酒精性肝炎。igf和受体的表达水平与患者潜在的肝脏疾病无关。在所有患者中，IGF-2在肿瘤和邻近的非肿瘤性肝脏中表达上调。10例肝硬化患者中有6例邻近肝脏IGF-1表达较低，17例无肝硬化患者中有2例表达较低（P = 0.025）。肿瘤邻近肝脏中较高的IGF-1表达与较差的中位生存期（22个月）相关，而肿瘤邻近肝脏中相同或较低的IGF-1表达与72个月相关（P = 0.006）。我们的初步结果表明，与潜在的肝脏疾病无关，IGF-1表达与HCC患者的肝硬化和术后生存率之间存在显著关联。
The insulin-like growth factor (IGF) pathway is implicated in the pathogenesis of hepatocellular carcinoma (HCC) and may be important in nonalcoholic fatty liver disease (NAFLD). The aim of this study is to determine expression levels of IGFs and receptors in NAFLD-associated HCC. Tissue microarrays were constructed from patients who underwent hepatectomy for HCC. Immunohistochemistry was performed using antibodies for IGF ligands and receptors. Immunostain results were scored by a pathologist blinded to clinical data. Among 27 patients with HCC, the most common underlying liver diseases included NAFLD, hepatitis C, and alcoholic hepatitis. Expression levels of IGFs and receptors were not associated with patients’ underlying liver disease. In all patients, IGF-2 expression was upregulated in tumor and adjacent non-neoplastic liver. Expression of IGF-1 was low in adjacent liver in 6 of 10 patients with cirrhosis, compared with 2 of 17 patients without cirrhosis (P = 0.025). Higher IGF-1 expression in liver adjacent to tumor was associated with poorer median survival of 22 months, compared with 72 months with equal or lower IGF-1 expression in adjacent liver relative to tumor (P = 0.006). Our preliminary results demonstrate significant associations between IGF-1 expression and liver cirrhosis and survival after resection in patients with HCC, independent of their underlying liver disease.
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