SIRT1 rs3758391 and Major Depressive Disorder: New Data and Meta-Analysis
SIRT1 rs3758391 and Major Depressive Disorder: New Data and Meta-Analysis
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SIRT1 rs3758391 和重度抑郁症：新数据和荟萃分析
DOI：
10.1007/s12264-018-0235-5
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发表时间：
2018-05
影响因子：
5.6
通讯作者：
Zhang Chen
中科院分区：
文献类型：
--
作者：
Tang Wei;Chen Yan;Fang Xinyu;Wang Yewei;Fan Weixing;Zhang Chen
遗传因素在重度抑郁障碍（MDD）的病理生理中起着重要作用。然而，其发生机制尚不清楚。最近，CONVERGE联盟对一个同质的中国样本（5303名MDD患者和5337名对照）进行了全基因组测序，发现沉默交配型信息调控2同源基因（SIRT1）附近的一个位点在全基因组显著水平[1]。在mRNA水平上，我们发现与健康参与者相比，MDD患者外周血中的SIRT1表达显著下调（下降37%）[2]。因此，这表明SIRT1是一种新的汉族MDD风险基因。rs3758391多态性位于SIRT1的5 '侧翼区域，该单核苷酸多态性（SNP）已被报道影响健康汉族bb0中SIRT1 mRNA的表达。在这项研究中，我们评估了中国汉族人群中SIRT1 rs3758391多态性与重度抑郁症的关系。从浙江省温州市康宁医院和金华市第二医院共招募702例患者。所有患者均根据精神障碍诊断与统计手册第四版（DSM-IV）标准诊断为重度抑郁症。纳入和排除标准在我们之前的出版物中报道过[4-7]。标准诊断评估补充了通过审查医疗记录和与举报人面谈获得的临床资料。从同一地区的一组献血者中招募了711名健康对照者，并没有进行精神病学筛查。对照组参与者自我报告无精神疾病、酒精依赖、药物滥用或精神疾病家族史。所有程序均由两所参与院校的院校覆核委员会审阅和批准。这项研究是按照1989年修订的《赫尔辛基宣言》中规定的准则进行的。所有受试者均为汉族，并在进行任何研究相关程序前提供书面知情同意书。使用天根DNA分离试剂盒（天根生物科技，北京，中国）从全血中分离基因组DNA。使用TaqMan法对SNP rs3758391进行基因分型，具体方法如前所述[8-11]。随后，我们进行了一项meta分析，以评估rs3758391与MDD的关联。文献在PubMed（http://www）上检索。ncbi。nlm。国家卫生研究院。gov/pubmed/)和SCOPUS （http://www）。斯高帕斯。以“SIRT1或沉默交配型信息调控2同源物1”、“多态性或变异”、“rs3758391”、“抑郁或MDD”等关键词进行各种组合。还检查了检索文章的参考书目或引用。所有论文均于2018年3月前发表。符合meta分析的研究
It is known that genetic factors play important roles in the pathophysiology of major depressive disorder (MDD). However, its genetic mechanism is still unknown. Recently, the CONVERGE consortium performed wholegenome sequencing in a homogenous Chinese sample (5303 MDD patients and 5337 controls) and one locus near the silent mating type information regulation 2 homolog 1 gene (SIRT1) was identified at a genome-wide significant level [1]. At the mRNA level, we found that SIRT1 expression is significantly down-regulated in the peripheral blood of patients with MDD compared with healthy participants (decreased by 37%)[2]. As such, this suggests that SIRT1 is a novel MDD risk gene in Han Chinese. The rs3758391 polymorphism is located in the 5’flanking region of SIRT1, and this single nucleotide polymorphism (SNP) has been reported to affect SIRT1 mRNA expression in healthy Han Chinese [3]. In this study, we assessed the association of the SIRT1 rs3758391 polymorphism with MDD in a Han Chinese population.A total of 702 patients were recruited from Wenzhou Kangning Hospital and Jinhua Second Hospital in Zhejiang Province. All patients were diagnosed with MDD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria. The inclusion and exclusion criteria were as reported in our previous publications [4–7]. The standard diagnostic assessments were supplemented with clinical information obtained by a review of medical records and interviews with family informants. Seven hundred and eleven healthy controls were recruited from a group of blood donors in the same regions and were not psychiatrically screened. The control participants were self-reported to be free of psychiatric disorders, alcohol dependence, drug abuse, or a family history of psychiatric disorders. All procedures were reviewed and approved by the Institutional Review Boards of both participating institutions. This study was performed in accordance with the guidelines laid out in the Declaration of Helsinki as revised in 1989. All participants were of Han Chinese origin and provided written informed consent before any study-related procedures were performed. Genomic DNA was isolated from whole blood using a Tiangen DNA isolation kit (Tiangen Biotech, Beijing, China). The SNP rs3758391 was genotyped using TaqMan assays, with details as described previously [8–11]. Subsequently, we conducted a meta-analysis to evaluate the association of rs3758391 with MDD. The literature was searched in PubMed(http://www. ncbi. nlm. nih. gov/pubmed/) and SCOPUS (http://www. scopus. com) with the keywords ‘‘SIRT1 or silent mating type information regulation 2 homolog 1’’,‘‘polymorphism or variant’’,‘‘rs3758391’’, and ‘‘depression or MDD’’in various combinations. Bibliographies or citations from the retrieved articles were also checked. All papers were published before March, 2018. Eligible studies for our meta-analysis
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DOI：
10.1159/000484119
发表时间：
2017-10
期刊：
Cell Physiol Biochem.
影响因子：
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通讯作者：
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