gammadelta T cell subsets: a link between TCR and function?
gammadelta T cell subsets: a link between TCR and function?
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DOI：
10.1016/j.smim.2010.03.006
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发表时间：
2010-08
影响因子：
7.8
通讯作者：
Born WK
中科院分区：
文献类型：
--
作者：
O'Brien RL;Born WK
The γδ T lmphocytes are often divided into subsets based upon expression of certain TCR components. This division was initially made because γδ T cells residing in particular epithelia were found to show tissue specific differences in their TCRs. Many examples now show that γδ T cell subsets also appear to be biased to carry out particular functions. This suggests that particular γδ TCR types direct the cells to acquire a certain type of functional programming during thymic development. Here, we describe functionally distinct, TCR-defined γδ T cell subsets, and evidence that their functions are pre-determined in the thymus.
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