Visual Impairment and Eye Diseases in HIV-infected People in the Antiretroviral Therapy (ART) Era in Rakai, Uganda.
Visual Impairment and Eye Diseases in HIV-infected People in the Antiretroviral Therapy (ART) Era in Rakai, Uganda.
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DOI：
10.1080/09286586.2020.1791908
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发表时间：
2021-03
影响因子：
1.8
通讯作者：
Kong X
中科院分区：
文献类型：
--
作者：
E JY;Wang Z;Ssekasanvu J;Munoz B;West S;Ludigo J;Gray R;Nakigozi G;Kong X
抗逆转录病毒治疗可减少 HIV 感染者的传染性眼病 (ED)。关于艾滋病毒感染者与年龄相关的 ED 和视力障碍 (VI) 的数据有限。我们报告了乌干达拉凯在 ART 时代 HIV 感染者的 VI 患病率和 ED 谱。 2009 年至 2012 年期间的一项慈善活动为接受护理的 HIV + 患者提供了眼科服务。 HIV 诊所训练有素的工作人员使用 6 米斯内伦视力表对单侧视力 (VA) 进行了评估。眼科医生通过裂隙灯检查评估了视力受损的眼睛。随后进行了回顾性图表审查，检索参与眼科服务的患者的数据。 VI 的定义参考了 WHO 的 ICD-11。眼科诊断按VI级进行总结。逻辑回归估计了人口统计学与白内障诊断的关联。 688 名 HIV+ 患者接受了评估，中位年龄为 44（IQR：37-50）岁，其中 69% 为女性。 51% 接受了 ART（中位持续时间 4，IQR：2-5 年）。中度/重度 VI 和失明的粗患病率均为 2%。主要诊断为屈光不正（55%）、结膜炎（18%）、白内障（15%）和翼状胬肉（11%）。 19-34岁、35-49岁和≥50岁年龄组的白内障患病率分别为10%、12%和26%。 73% 的失明 HIV+ 患者和 63% 的中度/重度 VI 患者患有白内障。年龄较大和男性与较高的白内障患病率显着相关。拉凯市HIV阳性患者的VI主要是由于屈光不正和白内障。白内障在所有年龄段都很常见。
Antiretroviral therapy reduced infectious eye diseases (EDs) in HIV infected people. There is limited data on age-related EDs and visual impairment (VI) in people living with HIV. We report prevalence of VI and spectrum of EDs in HIV infected people in an ART era in Rakai, Uganda. A philanthropic campaign during 2009-2012 provided ophthalmic services to HIV+ patients in care. Unilateral presenting visual acuity (VA) was assessed by a trained staff in HIV clinics using a 6-meter Snellen chart. A slit lamp examination by an ophthalmologist evaluated eyes with impaired acuity. A retrospective chart review was later conducted retrieving data of patients participating the ophthalmic service. VI was defined referencing WHO’s ICD-11. Ophthalmic diagnosis was summarized by VI level. Logistic regressions estimated demographic associations with cataract diagnosis. 688 HIV+ patients were evaluated, median age was 44 (IQR: 37-50) years, 69% were female. 51% were on ART (median duration 4, IQR: 2-5 years). Crude prevalence of moderate/severe VI and blindness were both 2%. The main diagnoses were refractive error (55%), conjunctivitis (18%), cataract (15%), and pterygium (11%). Cataract prevalences were 10%, 12% and 26% among age groups of 19-34, 35-49 and ≥ 50 years, respectively. Cataract was found in 73% of the HIV+s with blindness and in 63% of those with moderate/severe VI. Older age and male sex were significantly associated with higher cataract prevalence. VI in HIV+ patients in Rakai was mainly due to refractive error and cataract. Cataract was common in all age groups.
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影响因子：
1.5
作者：
Conroy, Samantha A.;Laeyendecker, Oliver;Quinn, Thomas C.
通讯作者：
Quinn, Thomas C.
影响因子：
13.7
作者：
Kempen, John H.;Sugar, Elizabeth A.;Lewis, Richard A.
通讯作者：
Lewis, Richard A.
DOI：
10.1056/nejmoa1702150
发表时间：
2017-11-30
期刊：
The New England journal of medicine
影响因子：
--
作者：
Grabowski MK;Serwadda DM;Gray RH;Nakigozi G;Kigozi G;Kagaayi J;Ssekubugu R;Nalugoda F;Lessler J;Lutalo T;Galiwango RM;Makumbi F;Kong X;Kabatesi D;Alamo ST;Wiersma S;Sewankambo NK;Tobian AAR;Laeyendecker O;Quinn TC;Reynolds SJ;Wawer MJ;Chang LW;Rakai Health Sciences Program
通讯作者：
Rakai Health Sciences Program
影响因子：
9.3
作者：
Ballocca, Flavia;D'Ascenzo, Fabrizio;Gaita, Fiorenzo
通讯作者：
Gaita, Fiorenzo
影响因子：
120.7
作者：
Kong, Xiangrong;Kigozi, Godfrey;Gray, Ronald H.
通讯作者：
Gray, Ronald H.