Podoplanin: emerging functions in development, the immune system, and cancer.
Podoplanin: emerging functions in development, the immune system, and cancer.
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DOI：
10.3389/fimmu.2012.00283
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发表时间：
2012
影响因子：
7.3
通讯作者：
Turley SJ
中科院分区：
文献类型：
--
作者：
Astarita JL;Acton SE;Turley SJ
泊多拉宁(PDPN)是一种高度保守的粘蛋白类跨膜蛋白，在个体发育过程中表达于多种组织，在成年动物的脑、心、肾、肺、成骨细胞和淋巴器官中均有表达。对PDPN缺陷小鼠的研究表明，该分子在心、肺和淋巴系统的发育中发挥关键作用。PDPN被广泛用作淋巴器官的淋巴管内皮细胞和成纤维细胞网状细胞的标记，以及皮肤和肿瘤微环境中的淋巴管的标记。对PDPN生物学的许多机制研究都是从对肿瘤细胞的研究中收集到的；肿瘤细胞在经历上皮-间充质转化时经常上调PDPN，这种上调与运动和转移的增加有关。PDPN的生理作用是聚集和激活表达CLEC-2的血小板的能力，因为PDPN是唯一已知的CLEC-2的内源性配体。然而，最近的研究表明，PDPN在免疫细胞的生物学中也发挥着关键作用，包括T细胞和树突状细胞。这篇综述将全面概述PDPN在发育、免疫学和癌症中的不同作用。
Podoplanin (PDPN) is a well-conserved, mucin-type transmembrane protein expressed in multiple tissues during ontogeny and in adult animals, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs. Studies of PDPN-deficient mice have demonstrated that this molecule plays a critical role in development of the heart, lungs, and lymphatic system. PDPN is widely used as a marker for lymphatic endothelial cells and fibroblastic reticular cells of lymphoid organs and for lymphatics in the skin and tumor microenvironment. Much of the mechanistic insight into PDPN biology has been gleaned from studies of tumor cells; tumor cells often upregulate PDPN as they undergo epithelial-mesenchymal transition and this upregulation is correlated with increased motility and metastasis. The physiological role of PDPN that has been most studied is its ability to aggregate and activate CLEC-2-expressing platelets, as PDPN is the only known endogenous ligand for CLEC-2. However, more recent studies have revealed that PDPN also plays crucial roles in the biology of immune cells, including T cells and dendritic cells. This review will provide a comprehensive overview of the diverse roles of PDPN in development, immunology, and cancer.
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影响因子：
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