Regulation of choroid plexus development and its functions.
Regulation of choroid plexus development and its functions.
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DOI：
10.1007/s00018-022-04314-1
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发表时间：
2022-05-19
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影响因子：
--
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脉络丛（ChP）是一种广泛血管化的组织，伸入所有脊椎动物的脑室系统。这种高度专业化的结构由极化上皮片和底层基质组成，在中枢神经系统 (CNS) 内发挥一系列功能，最显着的是脑脊液 (CSF) 的产生。 ChP 的上皮细胞具有严格调节 CSF 生物分子组成的能力，CSF 充当功能性连接 ChP 与其他大脑结构的环境。本综述旨在雄辩地总结当前有关 ChP 发展的知识。我们描述了从屋顶板控制其早期规格的机制，随后形成增殖区域（皮质下摆和菱形唇），为 ChP 的后期发育提供营养。接下来，我们总结了目前关于 ChP 成熟以及控制其形态和细胞多样性的机制的知识。此外，我们试图回顾目前可用于 ChP 研究的分子标记和小鼠品系，并确定一些必须克服的技术缺陷，以加速 ChP 研究领域的发展。总体而言，本次综述的中心原则是强调 ChP 是一个有趣且鲜为人知的结构，它对整个中枢神经系统的发育和功能至关重要。我们相信，我们的总结将增加人们对 ChP 进一步研究的兴趣，这些研究旨在描述指导该组织发育和功能的分子和细胞原理。
The choroid plexus (ChP) is an extensively vascularized tissue that protrudes into the brain ventricular system of all vertebrates. This highly specialized structure, consisting of the polarized epithelial sheet and underlying stroma, serves a spectrum of functions within the central nervous system (CNS), most notably the production of cerebrospinal fluid (CSF). The epithelial cells of the ChP have the competence to tightly modulate the biomolecule composition of CSF, which acts as a milieu functionally connecting ChP with other brain structures. This review aims to eloquently summarize the current knowledge about the development of ChP. We describe the mechanisms that control its early specification from roof plate followed by the formation of proliferative regions—cortical hem and rhombic lips—feeding later development of ChP. Next, we summarized the current knowledge on the maturation of ChP and mechanisms that control its morphological and cellular diversity. Furthermore, we attempted to review the currently available battery of molecular markers and mouse strains available for the research of ChP, and identified some technological shortcomings that must be overcome to accelerate the ChP research field. Overall, the central principle of this review is to highlight ChP as an intriguing and surprisingly poorly known structure that is vital for the development and function of the whole CNS. We believe that our summary will increase the interest in further studies of ChP that aim to describe the molecular and cellular principles guiding the development and function of this tissue.
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DOI：
10.1073/pnas.0910786107
发表时间：
2010-06-08
影响因子：
11.1
作者：
Chizhikov, Victor V.;Lindgren, Anne G.;Millen, Kathleen J.
通讯作者：
Millen, Kathleen J.
影响因子：
5.5
作者：
Bouzinova, EV;Praetorius, J;Aalkjaer, C
通讯作者：
Aalkjaer, C
影响因子：
3.9
作者：
BLAMIRES, TL;MAHER, ER
通讯作者：
MAHER, ER
影响因子：
3.7
作者：
Barkho BZ;Monuki ES
通讯作者：
Monuki ES
影响因子：
--
作者：
Biondi, G
通讯作者：
Biondi, G