Limbal stem cell diseases.
Limbal stem cell diseases.
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DOI：
10.1016/j.exer.2021.108437
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发表时间：
2021-04
影响因子：
3.4
通讯作者：
Deng SX
中科院分区：
文献类型：
--
作者：
Bonnet C;Roberts JS;Deng SX
角膜缘干/祖细胞(LSCs)的功能是维持角膜上皮细胞动态平衡的关键。许多外在的侮辱和内在缺陷会对LSCs及其生态位微环境造成伤害，导致角膜缘干细胞功能障碍或缺陷(LSCD)。眼部合并症是LSCD的常见并发症，可加重残存LSCs的功能障碍，限制移植LSCs的存活。LSCD的临床表现和疾病演变因病因不同而不同。新的眼部成像模式和分子标记现在可以用来标准化诊断标准和疾病的严重程度。如果存在残留的LSCs，药物治疗可能足以逆转疾病。在考虑手术干预之前，应遵循循序渐进的方法，优化眼表，消除致病因素，治疗并存情况。此外，根据疾病的严重程度和偏侧性来选择手术方案。为了客观地评估和比较新出现的定制疗法的疗效，有必要制定标准化的诊断标准来分期。
The function of limbal stem/progenitor cells (LSCs) is critical to maintain corneal epithelial homeostasis. Many external insults and intrinsic defects can be deleterious to LSCs and their niche microenvironment, resulting in limbal stem cell dysfunction or deficiency (LSCD). Ocular comorbidities, frequent in eyes with LSCD, can exacerbate the dysfunction of residual LSCs, and limit the survival of transplanted LSCs. Clinical presentation and disease evolution vary among different etiologies of LSCD. New ocular imaging modalities and molecular markers are now available to standardize the diagnosis criteria and stage the severity of the disease. Medical therapies may be sufficient to reverse the disease if residual LSCs are present. A stepwise approach should be followed to optimize the ocular surface, eliminate the causative factors and treat comorbid conditions, before considering surgical interventions. Furthermore, surgical options are selected depending on the severity and laterality of the disease. The standardized diagnostic criteria to stage the disease is necessary to objectively evaluate and compare the efficacy of the emerging customized therapies.
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影响因子：
2.8
作者：
Cheung, Albert Y.;Patel, Sunny;Holland, Edward J.
通讯作者：
Holland, Edward J.
影响因子：
3
作者：
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DOI：
10.3791/53370
发表时间：
2015-12-18
期刊：
Journal of visualized experiments : JoVE
影响因子：
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通讯作者：
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影响因子：
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作者：
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作者：
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