Therapeutic Potential of Extracellular Vesicles for the Treatment of Corneal Injuries and Scars.
Therapeutic Potential of Extracellular Vesicles for the Treatment of Corneal Injuries and Scars.
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DOI：
10.1167/tvst.9.12.1
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发表时间：
2020-11
影响因子：
3
通讯作者：
Gee S
中科院分区：
文献类型：
--
作者：
Deng SX;Dos Santos A;Gee S
眼表面的感染、创伤和化学暴露可严重损害角膜，导致视觉上显著的基质疤痕。目前的药物治疗在减轻角膜疤痕方面效果不佳，角膜移植是唯一能够恢复这些眼睛视力的治疗方法。然而，由于角膜组织的严重短缺，与角膜移植相关的致盲并发症的风险，以及更高的移植失败率，预防和治疗角膜瘢痕形成的有效和可行的替代疗法仍然是全球范围内尚未满足的重大医学需求。近年来，细胞分泌的胞外小泡(EVS)介导细胞间通讯的治疗潜力成为人们越来越感兴趣的话题。来源于间充质干细胞，特别是人角膜基质干细胞的EVS在损伤的角膜中具有抗纤维化、抗炎和再生的作用。这些功能性电动汽车的确切作用机制在很大程度上尚不清楚。EVS的治疗开发还处于早期阶段，需要进一步的临床前研究。
Infection, trauma, and chemical exposure of the ocular surface can severely damage the cornea, resulting in visually significant stromal scars. Current medical treatments are ineffective in mitigating corneal scarring, and corneal transplantation is the only therapy able to restore vision in these eyes. However, because of a severe shortage of corneal tissues, risks of blinding complications associated with corneal transplants, and a higher rate of graft failure in these eyes, an effective and deliverable alternative therapy for the prevention and treatment of corneal scarring remains a significant unmet medical need globally. In recent years, the therapeutic potential of extracellular vesicles (EVs) secreted by cells to mediate cell-cell communication has been a topic of increasing interest. EVs derived from mesenchymal stem cells, in particular human corneal stromal stem cells, have antifibrotic, anti-inflammatory, and regenerative effects in injured corneas. The exact mechanism of action of these functional EVs are largely unknown. Therapeutic development of EVs is at an early stage and warrants further preclinical studies.
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DOI：
10.1002/stem.2781
发表时间：
2018-05
期刊：
Stem cells (Dayton, Ohio)
影响因子：
--
作者：
Eslani M;Putra I;Shen X;Hamouie J;Tadepalli A;Anwar KN;Kink JA;Ghassemi S;Agnihotri G;Reshetylo S;Mashaghi A;Dana R;Hematti P;Djalilian AR
通讯作者：
Djalilian AR
DOI：
10.1016/j.apsb.2016.02.001
发表时间：
2016-07
期刊：
Acta pharmaceutica Sinica. B
影响因子：
--
作者：
Ha D;Yang N;Nadithe V
通讯作者：
Nadithe V
DOI：
10.1111/nyas.13121
发表时间：
2016-01-01
期刊：
COUNTERMEASURES AGAINST CHEMICAL THREATS
影响因子：
--
作者：
Goswami, Dinesh G.;Tewari-Singh, Neera;Agarwal, Rajesh
通讯作者：
Agarwal, Rajesh
影响因子：
2.8
作者：
Goswami, Dinesh G.;Tewari-Singh, Neera;Agarwal, Rajesh
通讯作者：
Agarwal, Rajesh
影响因子：
2.8
作者：
Deng, Sophie X.;Borderie, Vincent;Attico, Eustachio
通讯作者：
Attico, Eustachio