Tumor-Derived Exosomes Modulate Primary Site Tumor Metastasis.

Tumor-Derived Exosomes Modulate Primary Site Tumor Metastasis.
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DOI:
10.3389/fcell.2022.752818
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发表时间:
2022
影响因子:
5.5
通讯作者:
Du J
Du J
中科院分区:
生物学2区
文献类型:
--
作者:
Bai S;Wang Z;Wang M;Li J;Wei Y;Xu R;Du J

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肿瘤源性外泌体(Tumor-derived exosomes,TDEs)是肿瘤细胞主动产生和释放的一种外泌体,它将肿瘤细胞的信息传递给正常细胞或异常细胞,参与肿瘤的转移。本文就TDEs在肿瘤转移中的作用机制作一综述。TDE将肿瘤衍生的蛋白质和非编码RNA转运到肿瘤细胞并促进迁移。转运到正常细胞,如血管内皮细胞和免疫细胞,促进血管生成,抑制免疫细胞活化,并提高肿瘤植入的机会。因此,TDE有助于肿瘤转移。本文综述了TDEs及其组分在肿瘤转移中的作用,并指出了TDEs在肿瘤转移中研究的不足。
Tumor-derived exosomes (TDEs) are actively produced and released by tumor cells and carry messages from tumor cells to healthy cells or abnormal cells, and they participate in tumor metastasis. In this review, we explore the underlying mechanism of action of TDEs in tumor metastasis. TDEs transport tumor-derived proteins and non-coding RNA to tumor cells and promote migration. Transport to normal cells, such as vascular endothelial cells and immune cells, promotes angiogenesis, inhibits immune cell activation, and improves chances of tumor implantation. Thus, TDEs contribute to tumor metastasis. We summarize the function of TDEs and their components in tumor metastasis and illuminate shortcomings for advancing research on TDEs in tumor metastasis.
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