Toggling between gamma-frequency activity and suppression of cell assemblies.
Toggling between gamma-frequency activity and suppression of cell assemblies.
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在伽马频活动和细胞组件抑制之间切换。
DOI：
10.3389/fncom.2013.00033
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发表时间：
2013
影响因子：
3.2
通讯作者：
Walker B
中科院分区：
文献类型：
--
作者：
Börgers C;Walker B
海马体和新皮层中的伽马（30-80 Hz）节律由兴奋性细胞和抑制性细胞（E-细胞和I-细胞）的相互作用产生，称为金字塔-神经元间网络伽马（PING），需要I-细胞响应E-细胞，但不自行发射。在理想化的模型中，在I细胞具有足够弱的PING驱动力的参数区域和它们具有如此大的驱动力以至于它们在没有E细胞的提示下发射的参数区域之间存在明显的边界。在后一种情况下，它们通常会去同步并抑制E细胞;因此Börgers和Kopell将该边界称为“抑制边界”。Börgers和Kopell在早期工作中使用的模型I-细胞具有“1型”相位响应，即，兴奋性的输入总是会促进它们。然而，快速尖峰抑制篮状细胞通常有一个“2型”相位反应：兴奋性输入在它们放电后不久到达延迟它们。我们研究了相位响应类型对抑制过渡的影响，在额外的假设下，I-细胞保持同步的间隙连接。当许多E细胞参与给定的周期时，如果I细胞的相位响应是1型，则所产生的激发在下一个周期中推进I细胞，并且这可以导致在下一个周期中抑制更多的E细胞。因此，强的E细胞尖峰截击之后往往是较弱的，反之亦然。这通常会导致E细胞尖峰截击强度的不稳定波动。当I-细胞的相位响应是2型时，相反的情况发生：强的E-细胞锋电位齐射延迟了下一个周期的抑制，因此倾向于跟随更强的抑制。E-细胞尖峰齐射的强度不振荡，并且有一个从PING到ING的几乎突然的过渡（仅涉及I-细胞的节奏）。
Gamma (30–80 Hz) rhythms in hippocampus and neocortex resulting from the interaction of excitatory and inhibitory cells (E- and I-cells), called Pyramidal-Interneuronal Network Gamma (PING), require that the I-cells respond to the E-cells, but don't fire on their own. In idealized models, there is a sharp boundary between a parameter regime where the I-cells have weak-enough drive for PING, and one where they have so much drive that they fire without being prompted by the E-cells. In the latter regime, they often de-synchronize and suppress the E-cells; the boundary was therefore called the “suppression boundary” by Börgers and Kopell. The model I-cells used in the earlier work by Börgers and Kopell have a “type 1” phase response, i.e., excitatory input always advances them. However, fast-spiking inhibitory basket cells often have a “type 2” phase response: Excitatory input arriving soon after they fire delays them. We study the effect of the phase response type on the suppression transition, under the additional assumption that the I-cells are kept synchronous by gap junctions. When many E-cells participate on a given cycle, the resulting excitation advances the I-cells on the next cycle if their phase response is of type 1, and this can result in suppression of more E-cells on the next cycle. Therefore, strong E-cell spike volleys tend to be followed by weaker ones, and vice versa. This often results in erratic fluctuations in the strengths of the E-cell spike volleys. When the phase response of the I-cells is of type 2, the opposite happens: strong E-cell spike volleys delay the inhibition on the next cycle, therefore tend to be followed by yet stronger ones. The strengths of the E-cell spike volleys don't oscillate, and there is a nearly abrupt transition from PING to ING (a rhythm involving I-cells only).
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影响因子：
3.4
作者：
Tateno, T.;Robinson, H. P. C.
通讯作者：
Robinson, H. P. C.
DOI：
10.1073/pnas.0406343101
发表时间：
2004-10-26
影响因子：
11.1
作者：
Kopell, N;Ermentrout, B
通讯作者：
Ermentrout, B
影响因子：
2.5
作者：
MCCORMICK, DA
通讯作者：
MCCORMICK, DA
影响因子：
5.5
作者：
HODGKIN, AL
通讯作者：
HODGKIN, AL
DOI：
10.1073/pnas.0809511105
发表时间：
2008-11-18
影响因子：
11.1
作者：
Borgers, Christoph;Epstein, Steven;Kopell, Nancy J.
通讯作者：
Kopell, Nancy J.