Effects of protease inhibitors on the course of CMV retinitis in relation to CD4+ lymphocyte responses in HIV+ patients
Effects of protease inhibitors on the course of CMV retinitis in relation to CD4+ lymphocyte responses in HIV+ patients
复制标题
蛋白酶抑制剂对 HIV 患者巨细胞病毒视网膜炎病程与 CD4 淋巴细胞反应的影响
DOI：
10.1136/bjo.82.9.988
复制
发表时间：
1998
影响因子：
4.1
通讯作者：
M. D. de Smet
中科院分区：
文献类型：
--
作者：
G. J. van den Horn;C. Meenken;S. Danner;P. Reiss;M. D. de Smet
AIM To gain insight into the course of CMV retinitis (CMVR) in AIDS patients receiving protease inhibitors (PI), and to evaluate whether certain patterns of CD4 response are indicative of the clinical outcome and the risk of recurrence. METHODS 15 consecutive AIDS patients receiving maintenance therapy for CMVR were included in a prospective observational cohort study at the university hospital between July and October 1996. Patients were evaluated for signs of CMVR activity and intraocular inflammation. CMVR recurrence was defined as the primary clinical endpoint. Follow up was performed until July 1997. No patient was lost to follow up. Clinical outcome was related to CD4+ lymphocyte counts, which were monitored every 6 weeks. Highly active antiretroviral treatment regimen including PI was started at study entry. RESULTS All recurrences (n=7) were in patients who failed to have a sustained increase in CD4 counts, whereas CMVR remained inactive during a follow up of 42–52 weeks in those who were able permanently to restore their CD4 values to 100×106/l or more (n=5). The remaining three patients died after 12, 16, and 50 weeks, respectively, without recurrences. All relapses of CMVR were seen after 6–16 weeks, and at CD4 counts well below 100×106/l. CONCLUSIONS The beneficial effects of PI treatment correlate with the pattern of CD4 response. Sustained increases in CD4 counts achieved in the first 16 weeks of treatment are associated with a prolonged period of CMVR quiescence. Poor initial response is associated with a high risk of CMVR recurrence.
对人类免疫缺陷病毒感染患者外周血细胞中的人类巨细胞病毒 DNA 进行定量可以预测巨细胞病毒性视网膜炎。
DOI：
10.1093/infdis/171.1.177
发表时间：
1995
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Rasmussen,L;Morris,S;Zipeto,D;Fessel,J;Wolitz,R;Dowling,A;Merigan,TC
通讯作者：
Merigan,TC