Late-Onset Suicide: A Dementia Prodrome?

Late-Onset Suicide: A Dementia Prodrome?
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DOI:
10.1016/j.jagp.2020.12.004
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发表时间:
2021-07
期刊:
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
影响因子:
--
通讯作者:
Szanto K
Szanto K
中科院分区:
其他
文献类型:
--
作者:
Gujral S;Butters MA;Dombrovski AY;Szanto K

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这项研究探讨了晚发性(与早发性)自杀行为是否与认知能力下降有关。参与者包括278名50岁以上的成年人(56名非精神病对照组; 67名非自杀性抑郁老年人; 63名抑郁自杀意念者; 44名晚发性(55岁以上)和48名早发性自杀意念者(<55岁))。本研究采用病例对照设计,采用Delis-Kaplan执行功能系统的神经心理状态重复成套测验和连线测验,考察了整体认知、情景记忆、信息处理速度和执行功能的组间差异。线性回归用于数据分析。这两组抑郁症患者的执行功能都比非自杀性抑郁症老年人差。晚发性抑郁症患者还表现出比非自杀性抑郁症老年人更差的整体认知和处理速度,以及比早发性抑郁症患者更差的记忆力。迟发性自杀行为与广泛认知领域的表现较差相关,可能反映了痴呆前驱症状。
This study examined whether late-onset (vs. early-onset) suicidal behavior is associated with worse cognition. Participants included 278 adults aged 50+ years (56 non-psychiatric comparison group; 67 non-suicidal depressed older adults; 63 depressed suicide ideators; and 44 late-onset (55+ years) and 48 early-onset suicide attempters (<55 years). Using a case-control design, this study examined group differences in global cognition, episodic memory, information processing speed, and executive functioning, assessed using the Repeatable Battery of Neuropsychological Status and the Trail Making Test from the Delis-Kaplan Executive Function System. Linear regression was used for data analyses. Both attempter groups displayed worse executive functioning than non-suicidal depressed older adults. Late-onset attempters additionally displayed poorer global cognition and processing speed than non-suicidal depressed older adults and poorer memory than early-onset attempters. Late-onset suicidal behavior is associated with worse performance in a broad range of cognitive domains, possibly reflective of a dementia prodrome.
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