Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review.
Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review.
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DOI：
10.1037/a0028727
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发表时间：
2013-01
影响因子：
22.4
通讯作者：
Snyder, Hannah R.
中科院分区：
文献类型：
--
作者：
Snyder, Hannah R.
认知功能障碍是抑郁症的一个重要方面，也有研究认为抑郁症患者的执行功能（EF）受损尤为严重。然而，与抑郁症相关的EF损伤的存在和性质仍然存在很大争议。虽然许多研究发现了与MDD相关的EF神经心理学指标的显著缺陷，但其他研究可能由于统计功效低、任务不纯和患者样本多样性而没有发现，并且最近没有研究MDD患者EF的综合荟萃分析。目前的荟萃分析使用随机效应模型来综合113项先前的研究，这些研究将MDD参与者与健康对照参与者在至少一项EF神经心理学指标上进行比较。荟萃分析的结果表明，MDD与EF神经心理学指标的表现受损可靠相关，效应量范围为d = 0.32-0.97。虽然MDD患者也有较慢的处理速度，但运动减慢不能单独解释这些结果。此外，一些证据表明，EF的神经心理学措施的赤字是更严重的当前抑郁症状的患者，那些服用精神药物，而年龄的影响的证据较弱。这一结果与MDD与EF多个方面的广泛损害相关的理论一致。MDD的治疗和EF理论的影响进行了讨论。未来的研究需要建立MDD和EF损伤之间的特异性和因果关系。
Cognitive impairments are now widely acknowledged as an important aspect of major depressive disorder (MDD), and it has been proposed that executive function (EF) may be particularly impaired in patients with MDD. However, the existence and nature of EF impairments associated with depression remain strongly debated. While many studies have found significant deficits associated with MDD on neuropsychological measures of EF, others have not, potentially due to low statistical power, task impurity, and diverse patient samples, and there have been no recent, comprehensive, meta-analyses investigating EF in patients with MDD. The current meta-analysis uses random effects models to synthesize 113 previous research studies that compared participants with MDD to healthy control participants on at least one neuropsychological measure of EF. Results of the meta-analysis demonstrate that MDD is reliably associated with impaired performance on neuropsychological measures of EF, with effect sizes ranging from d = 0.32–0.97. While patients with MDD also have slower processing speed, motor slowing alone cannot account for these results. In addition, some evidence suggests that deficits on neuropsychological measures of EF are greater in patients with more severe current depression symptoms, and those taking psychotropic medications, while evidence for effects of age was weaker. The results are consistent with the theory that MDD is associated with broad impairment in multiple aspects of EF. Implications for treatment of MDD and theories of EF are discussed. Future research is needed to establish the specificity and causal link between MDD and EF impairments.
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影响因子：
4
作者：
Ayotte, Brian J.;Potter, Guy G.;Williams, Heather T.;Steffens, David C.;Bosworth, Hayden B.
通讯作者：
Bosworth, Hayden B.
DOI：
10.1176/appi.neuropsych.22.1.70
发表时间：
2010-12-01
影响因子：
2.9
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作者：
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通讯作者：
Hadzi-Pavlovic, D
DOI：
10.1076/1380-3395(200008)22:4;1-0;ft518
发表时间：
2000-01-01
影响因子：
2.2
作者：
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通讯作者：
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