Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury.
Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury.
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DOI：
10.1007/s10753-022-01708-y
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发表时间：
2022-12
期刊：
影响因子：
5.1
通讯作者：
中科院分区：
文献类型：
--
作者：
肺上皮不断暴露于环境中，对于协调对感染性生物体、毒素和过敏刺激的初始反应以及维持正常的气体交换和肺功能至关重要。肺上皮细胞的完整性、液体平衡和分子转运由紧密连接（TJ）决定。TJ形成于相邻的细胞之间。我们集中在肺上皮细胞的TJ结构和功能的主题。本文综述了近20年来发表的关于各种肺部疾病中TJ和上皮屏障破坏以及特异性TJ蛋白对致病刺激的表达和调节的文献报道。我们讨论了控制TJ结构和功能的分子信号和信号通路之间的串扰。Toll样受体-4（TLR 4）识别肺损伤和炎症过程中释放的病原体和损伤相关分子模式，并协调细胞反应。在TJ或上皮屏障的背景下，TLR 4信号传导的分子方面还不完全清楚。我们描述了目前的知识和可能的网络TLR 4信号与TJ的细胞和分子机制，肺上皮屏障功能和治疗策略的阻力。
Lung epithelium is constantly exposed to the environment and is critically important for the orchestration of initial responses to infectious organisms, toxins, and allergic stimuli, and maintenance of normal gaseous exchange and pulmonary function. The integrity of lung epithelium, fluid balance, and transport of molecules is dictated by the tight junctions (TJs). The TJs are formed between adjacent cells. We have focused on the topic of the TJ structure and function in lung epithelial cells. This review includes a summary of the last twenty years of literature reports published on the disrupted TJs and epithelial barrier in various lung conditions and expression and regulation of specific TJ proteins against pathogenic stimuli. We discuss the molecular signaling and crosstalk among signaling pathways that control the TJ structure and function. The Toll-like receptor-4 (TLR4) recognizes the pathogen- and damage-associated molecular patterns released during lung injury and inflammation and coordinates cellular responses. The molecular aspects of TLR4 signaling in the context of TJs or the epithelial barrier are not fully known. We describe the current knowledge and possible networking of the TLR4-signaling with cellular and molecular mechanisms of TJs, lung epithelial barrier function, and resistance to treatment strategies.
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