Cytokine regulation of tight junctions.

Cytokine regulation of tight junctions.
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DOI:
10.1016/j.bbamem.2008.08.027
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发表时间:
2009-04
影响因子:
3.4
通讯作者:
Nusrat, Asma
Nusrat, Asma
中科院分区:
生物学3区
文献类型:
--
作者:
Capaldo, Christopher T.;Nusrat, Asma

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上皮和内皮紧密连接作为生物体与其环境之间的限速屏障。持续的研究强调了细胞因子对紧密连接屏障的调节。阐明这种相互作用是至关重要的生理紧密连接调节和病理条件的病因学的理解。本文就细胞因子调节紧密连接的分子机制的研究进展作一综述。
Epithelial and endothelial tight junctions act as a rate-limiting barrier between an organism and its environment. Continuing studies have highlighted the regulation of the tight junction barrier by cytokines. Elucidation of this interplay is vital for both the understanding of physiological tight junction regulation and the etiology of pathological conditions. This review will focus on recent advances in our understanding of the molecular mechanisms of tight junctions modulation by cytokines.
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