Solvatochromic fluorescent probes for recognition of human serum albumin in aqueous solution: Insights into structure-property relationship.
Solvatochromic fluorescent probes for recognition of human serum albumin in aqueous solution: Insights into structure-property relationship.
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DOI：
10.1016/j.snb.2016.06.056
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发表时间：
2016-11-29
期刊：
影响因子：
--
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Liu B;Bi X;McDonald L;Pang Y;Liu D;Pan C;Wang L
人血清白蛋白（HSA）作为人体血浆中最丰富的蛋白质，具有多种生理功能。血清或尿液中HSA的失调与多种疾病有关，例如肝硬化、多发性骨髓瘤和心血管疾病。因此，高选择性、高灵敏度地定量体液中的HSA对于疾病诊断和预防医学具有重要意义。我们在此开发了一系列酰胺功能化黄酮类探针 1-3，用于识别人血清白蛋白。所有黄酮类化合物都可以通过 Claisen-Schmidt 缩合和 Algar-Flynn-Oyamada 反应轻松制备，并且在其双重发射上显示出正溶剂化显色现象。黄酮类化合物的化学结构对其 HSA 传感能力起着重要作用。在三种探针中，化合物1对水溶液中的HSA表现出最高的灵敏度、显着的选择性和定量响应。加上其对环境 pH 值的高耐受性、抗干扰特性和时间不敏感性，因此它为 HSA 提供了一种有前途的传感方法。
Human serum albumin (HSA) as the most abundant protein in human blood plasma, serves many physiological functions. The dysregulation of HSA in serum or in urine is associated with various diseases, such as cirrhosis of liver, multiple myeloma, and cardiovascular disease. Therefore, to quantify HSA in body fluids with high selectivity and sensitivity is of great significance for disease diagnosis and preventive medicine. We herein developed a series of amide-functionalized flavonoids probes, 1–3, for recognition of human serum albumin. All flavonoids could be easily prepared by a Claisen-Schmidt condensation and Algar-Flynn-Oyamada reaction, and showed positive solvatochromism on their dual emissions. The chemical structure of flavonoids played an important role on their HSA-sensing abilities. Among three probes, the compound 1 showed the highest sensitivity, the remarkable selectivity, and the quantitive response for HSA in aqueous solution. Together with its high tolerance of environmental pH, anti-interference properties, and time-insensitivity, thus it provides a promising sensing method for HSA.
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