Biological Activities and Potential Oral Applications of N-Acetylcysteine: Progress and Prospects.
Biological Activities and Potential Oral Applications of N-Acetylcysteine: Progress and Prospects.
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DOI：
10.1155/2018/2835787
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发表时间：
2018
影响因子：
--
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Pei Y;Liu H;Yang Y;Yang Y;Jiao Y;Tay FR;Chen J
N-乙酰半胱氨酸(NAC)是一种半胱氨酸前体药物和谷胱甘肽(GSH)前体，几十年来一直被用于临床治疗实践中，作为粘液剂和治疗与GSH缺乏相关的疾病。NAC的其他治疗作用包括抑制炎症/NF-κB信号和促炎细胞因子的表达。N-乙酰半胱氨酸也是一种具有抗菌性能的非抗生素化合物，对某些类型的癌症具有抗癌和抗突变作用。最近，关于NAC潜在的重要生物学和药理活性的研究激发了人们对以NAC为基础的治疗方法用于口腔保健的兴趣。本文就NAC的生物活性及其潜在的口服应用作一综述。还讨论了NAC的潜在副作用和给药配方，目的是促进口腔医学中与NAC相关的治疗方式的发展。
N-Acetylcysteine (NAC), a cysteine prodrug and glutathione (GSH) precursor, has been used for several decades in clinical therapeutic practices as a mucolytic agent and for the treatment of disorders associated with GSH deficiency. Other therapeutic activities of NAC include inhibition of inflammation/NF-κB signaling and expression of proinflammatory cytokines. N-Acetylcysteine is also a nonantibiotic compound possessing antimicrobial property and exerts anticarcinogenic and antimutagenic effects against certain types of cancer. Recently, studies describing potentially important biological and pharmacological activities of NAC have stimulated interests in using NAC-based therapeutics for oral health care. The present review focused on the biological activities of NAC and its potential oral applications. The potential side effects of NAC and formulations for drug delivery were also discussed, with the intent of advancing NAC-associated treatment modalities in oral medicine.
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影响因子：
3.4
作者：
CHEN, SN;HOFFMAN, MZ
通讯作者：
HOFFMAN, MZ
影响因子：
2.3
作者：
AlMatar, Manaf;Batool, Tahira;Makky, Essam A.
通讯作者：
Makky, Essam A.
影响因子：
--
作者：
Barbizam, João Vicente Baroni;Trope, Martin;Teixeira, Fabrício B.
通讯作者：
Teixeira, Fabrício B.
DOI：
10.1046/j.1365-2362.2000.00736.x
发表时间：
2000-10-01
影响因子：
5.5
作者：
De Rosa, SC;Zaretsky, MD;Herzenberg, LA
通讯作者：
Herzenberg, LA
影响因子：
4.7
作者：
DEFLORA, S;BENNICELLI, C;DEFLORA, A
通讯作者：
DEFLORA, A