Childhood adversity and DNA methylation in two population-based cohorts.
Childhood adversity and DNA methylation in two population-based cohorts.
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DOI：
10.1038/s41398-018-0307-3
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发表时间：
2018-12-03
影响因子：
6.8
通讯作者：
Howe LD
中科院分区：
文献类型：
--
作者：
Houtepen LC;Hardy R;Maddock J;Kuh D;Anderson EL;Relton CL;Suderman MJ;Howe LD
童年时期的逆境会影响日后的健康，但其潜在的分子机制尚不清楚。虽然有一些来自动物模型和病例对照研究的证据表明DNA甲基化的作用，但来自人类群体研究的证据是有限的。在两个队列中(来自雅芳父母和儿童纵向研究的母亲，ALSPAC，n = 780和来自MRC全国健康与发展调查的妇女，NSHD，n = 552)，我们评估了七种不良童年经历(ACE：父母身体疾病，父母精神疾病，父母死亡，父母分离，母亲关系不佳，儿童疾病和儿童虐待)及其组合(ACE评分)与使用Illumina Infinium Human Metylation450 BeadChip在平均年龄47岁的外周血液和53岁的口腔细胞中测量的全基因组DNA甲基化水平的关系。在另一个队列中，检查了全基因组错误发现率低于0.05的CpG位点和每个队列中Šidák一步校正p值低于0.05的差异甲基化区域(DMR)。没有单独的CpG位点在队列中复制。然而，在队列中复制的9个DMR分别与ACE得分(一个地区)、父母精神疾病(两个地区)、父母身体疾病(三个地区)和父母死亡(三个地区)相关。这些观察表明，一些不良的童年经历，特别是那些与父母健康有关的经历，可能会在外周DNA甲基化上留下印记，并持续到中年。
Childhood adversity affects later health, but the underlying molecular mechanisms are unclear. Although there is some evidence from animal models and case-control studies of a role for DNA methylation, evidence from human population-based studies is limited. In two cohorts (mothers from the Avon Longitudinal Study of Parents and Children, ALSPAC, n = 780 and women from the MRC National Survey of Health and Development, NSHD, n = 552), we assessed the association of seven adverse childhood experiences (ACEs: parental physical illness, parental mental illness, parental death, parental separation, suboptimal maternal bonding, childhood illness and child maltreatment) as well as their combination (ACE score) with genome-wide DNA methylation levels measured using the Illumina Infinium HumanMethylation450 BeadChip in peripheral blood at mean age 47 years (ALSPAC) and in buccal cells at age 53 years (NSHD). CpG sites with a genome-wide false discovery rate (FDR) below 0.05 and differentially methylated regions (DMRs) with one-step Šidák correction p-values below 0.05 in each cohort were examined in the other cohort. No individual CpG sites replicated across cohorts. However, nine DMRs replicated across cohorts respectively associated with the ACE score (one region), parental mental illness (two regions), parental physical illness (three regions) and parental death (three regions). These observations indicate that some adverse childhood experiences, notably those related to parental health, may leave imprints on peripheral DNA methylation that persist to mid-life.
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遭受童年契约劳动和创伤的老年人的 DNA 甲基化谱。
影响因子：
--
作者：
Marinova Z;Maercker A;Küffer A;Robinson MD;Wojdacz TK;Walitza S;Grünblatt E;Burri A
通讯作者：
Burri A
影响因子：
6.8
作者：
Kumsta R;Marzi SJ;Viana J;Dempster EL;Crawford B;Rutter M;Mill J;Sonuga-Barke EJ
通讯作者：
Sonuga-Barke EJ
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
25
作者：
Klengel, Torsten;Mehta, Divya;Anacker, Christoph;Rex-Haffner, Monika;Pruessner, Jens C.;Pariante, Carmine M.;Pace, Thaddeus W. W.;Mercer, Kristina B.;Mayberg, Helen S.;Bradley, Bekh;Nemeroff, Charles B.;Holsboer, Florian;Heim, Christine M.;Ressler, Kerry J.;Rein, Theo;Binder, Elisabeth B.
通讯作者：
Binder, Elisabeth B.
影响因子：
168.9
作者：
Gilbert, Ruth;Widom, Cathy Spatz;Janson, Staffan
通讯作者：
Janson, Staffan