Estrogen receptor β deficiency impairs gut microbiota: a possible mechanism of IBD-induced anxiety-like behavior.
Estrogen receptor β deficiency impairs gut microbiota: a possible mechanism of IBD-induced anxiety-like behavior.
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雌激素受体β缺乏损害肠道微生物群：IBD诱导的焦虑样行为的可能机制
DOI：
10.1186/s40168-022-01356-2
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发表时间：
2022-09-29
期刊：
影响因子：
15.5
通讯作者：
中科院分区：
文献类型：
--
作者：
虽然雌激素受体β(ERβ)的缺乏是炎症性肠病和精神障碍的危险因素，但其潜在的细胞和分子机制仍不完全清楚。在这里，我们揭示了肠道微生物区系在内质网β缺陷小鼠IBD和相关焦虑样行为发展中的作用。作为对葡聚糖硫酸钠攻击的反应，ERβ基因敲除小鼠的粪便微生物区系组成中的α和β多样性发生了显著变化，结肠炎和焦虑样行为恶化。此外，DSS诱导的结肠炎还导致ERβ缺陷小鼠下丘脑-垂体-肾上腺(HPA)轴活动增加，这与结肠炎和焦虑样行为有关。此外，测序数据表明，ErbB4可能是ERβ的靶点，参与调节DSS侮辱引起的下丘脑轴过度活动。共居小鼠肠道微生物区系重塑显示，同住野生型小鼠相比，共住野生型小鼠的结肠炎和焦虑样行为均加重。这些发现表明，肠道微生物区系通过肠道-脑轴内异常的神经处理，在调节结肠炎疾病活动和焦虑样行为方面发挥关键作用。ERβ有可能通过重建肠道微生物区系来抑制结肠炎的发展和焦虑样行为，这表明ERβ是治疗IBD和相关焦虑样行为的一个有前景的治疗靶点。视频摘要在线版本包含可在10.1186/s40168022-01356-2上查阅的补充材料。
Although the lack of estrogen receptor β (ERβ) is a risk factor for the development of inflammatory bowel disease (IBD) and psychiatric disorders, the underlying cellular and molecular mechanisms are not fully understood. Herein, we revealed the role of gut microbiota in the development of IBD and related anxiety-like behavior in ERβ-deficient mice. In response to dextran sodium sulfate (DSS) insult, the ERβ knockout mice displayed significant shift in α and β diversity in the fecal microbiota composition and demonstrated worsening of colitis and anxiety-like behaviors. In addition, DSS-induced colitis also induced hypothalamic-pituitary-adrenal (HPA) axis hyperactivity in ERβ-deficient mice, which was associated with colitis and anxiety-like behaviors. In addition, RNA sequencing data suggested that ErbB4 might be the target of ERβ that is involved in regulating the HPA axis hyperactivity caused by DSS insult. Gut microbiota remodeling by co-housing showed that both the colitis and anxiety-like behaviors were aggravated in co-housed wild-type mice compared to single-housed wild-type mice. These findings suggest that gut microbiota play a critical role in mediating colitis disease activity and anxiety-like behaviors via aberrant neural processing within the gut-brain axis. ERβ has the potential to inhibit colitis development and anxiety-like behaviors via remodeling of the gut microbiota, which suggests that ERβ is a promising therapeutic target for the treatment of IBD and related anxiety-like behaviors. Video Abstract The online version contains supplementary material available at 10.1186/s40168-022-01356-2.
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微生物群调节下丘脑-垂体-肾上腺轴的焦虑样行为和内分泌异常。
影响因子：
5.7
作者：
Huo R;Zeng B;Zeng L;Cheng K;Li B;Luo Y;Wang H;Zhou C;Fang L;Li W;Niu R;Wei H;Xie P
通讯作者：
Xie P
DOI：
10.4049/jimmunol.1701625
发表时间：
2018-04-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bhatt B;Zeng P;Zhu H;Sivaprakasam S;Li S;Xiao H;Dong L;Shiao P;Kolhe R;Patel N;Li H;Levy-Bercowski D;Ganapathy V;Singh N
通讯作者：
Singh N
影响因子：
5.3
作者：
Bean, Jonathan C.;Lin, Thiri W.;Mei, Lin
通讯作者：
Mei, Lin
影响因子：
65.1
作者：
de Souza, Heitor S. P.;Fiocchi, Claudio;Iliopoulos, Dimitrios
通讯作者：
Iliopoulos, Dimitrios
影响因子：
17.1
作者：
De Palma, Giada;Lynch, Michael D. J.;Bercik, Premysl
通讯作者：
Bercik, Premysl