Orofacial Clefts in High Prevalence Area of Birth Defects - Five Counties, Shanxi Province, China, 2000-2020.
Orofacial Clefts in High Prevalence Area of Birth Defects - Five Counties, Shanxi Province, China, 2000-2020.
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DOI:
10.46234/ccdcw2021.192
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发表时间:
2021-09-10
期刊:
影响因子:
4.7
通讯作者:
Ren A
中科院分区:
文献类型:
--
作者:
Liu J;Zhang Y;Zhang L;Wang L;Jin L;Greene NDE;Li Z;Ren A
The prevalence of structural birth defects, especially neural tube defects, decreased after national folic acid (FA) supplementation initiation. The prevalence of orofacial clefts (OFCs) in five counties of Shanxi Province in northern China, including most subtypes except cleft palate, showed a downward trend in the past two decades. In this study, pre-perinatal prevalence increased due to earlier detection. Periconceptional supplementation with FA may contribute to the decline in OFCs prevalence, while the effect on the OFCs subtype needs further investigation. Continuing to advocate for earlier supplementation (3 months before conception) and increased supplementation frequency (daily consumption) could promote further reduction in the prevalence of OFCs. Specific surveillance of this effect in the era of universal three-child policy is warranted.
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