Orofacial Clefts in High Prevalence Area of Birth Defects - Five Counties, Shanxi Province, China, 2000-2020.

Orofacial Clefts in High Prevalence Area of Birth Defects - Five Counties, Shanxi Province, China, 2000-2020.
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DOI:
10.46234/ccdcw2021.192
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发表时间:
2021-09-10
期刊:
影响因子:
4.7
通讯作者:
Ren A
Ren A
中科院分区:
医学4区
文献类型:
--
作者:
Liu J;Zhang Y;Zhang L;Wang L;Jin L;Greene NDE;Li Z;Ren A

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结构性出生缺陷,特别是神经管缺陷的患病率在全国叶酸(FA)补充开始后下降。近20年来,山西省5个县(含除腭裂以外的大多数亚型)的口面腭裂患病率呈下降趋势。在这项研究中,由于早期检测,围产期前患病率增加。围孕期补充FA可能有助于OFCs患病率的下降,但对OFCs亚型的影响有待进一步研究。继续提倡更早补充(怀孕前3个月)和增加补充频率(每日摄入量)可以促进OFCs患病率的进一步降低。在全面三孩政策时代,有必要对这种影响进行具体监测。
The prevalence of structural birth defects, especially neural tube defects, decreased after national folic acid (FA) supplementation initiation. The prevalence of orofacial clefts (OFCs) in five counties of Shanxi Province in northern China, including most subtypes except cleft palate, showed a downward trend in the past two decades. In this study, pre-perinatal prevalence increased due to earlier detection. Periconceptional supplementation with FA may contribute to the decline in OFCs prevalence, while the effect on the OFCs subtype needs further investigation. Continuing to advocate for earlier supplementation (3 months before conception) and increased supplementation frequency (daily consumption) could promote further reduction in the prevalence of OFCs. Specific surveillance of this effect in the era of universal three-child policy is warranted.
部分结构性出生缺陷 - 中国山西省,2000-2019 年。
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