Maternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring.
Maternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring.
复制标题
DOI：
10.1038/s41598-021-91825-9
复制
发表时间：
2021-06-10
影响因子：
4.6
通讯作者：
Dai L
中科院分区：
文献类型：
--
作者：
Xu W;Yi L;Deng C;Zhao Z;Ran L;Ren Z;Zhao S;Zhou T;Zhang G;Liu H;Dai L
孕妇围孕期叶酸补充（FAS）已被证明与降低非综合征性唇裂（NsOC）的风险相关。然而，结果仍然没有定论。在这项以人群为基础的病例对照研究中，我们对2010年10月至2015年9月在中国成都出生的807例NsOC单胎和8070例健康新生儿进行了研究，研究了母亲FAS与非综合征性唇裂伴或不伴腭裂（NsCL/P）和腭裂（NsCP）风险的关系。使用无条件逻辑回归分析来估计粗比值比（or）和调整后的95%置信区间（CI）。母体围孕期FAS与NsCL/P风险降低之间存在显著相关性（aOR = 0.41, 95% CI 0.33-0.51）。这种保护作用在nsclc （aOR = 0.42, 95% CI 0.30-0.58）和NsCLP （aOR = 0.41, 95% CI 0.31-0.54）中也被检测到。产妇末次月经前后FAS均与NsCL/P呈负相关（末次月经前，aOR = 0.43, 95% CI 0.33-0.56；末次月经后，aOR = 0.41, 95% CI 0.33-0.51）。NsCP与LMP前母体FAS发生之间也存在关联（aOR = 0.52, 95% CI 0.30-0.90）。研究结果表明，母体围孕期FAS可降低后代罹患NsCL/P各亚型的风险，但对NsCP的潜在影响有待进一步研究。
Maternal periconceptional folic acid supplementation (FAS) has been documented to be associated with decreased risk of nonsyndromic oral clefts (NsOC). However, the results remain inconclusive. In this population-based case–control study of 807 singletons affected by NsOC and 8070 healthy neonates who were born between October 2010 and September 2015 in Chengdu, China, we examined the association of maternal FAS with the risk of nonsyndromic cleft lip with or without cleft palate (NsCL/P), and cleft palate (NsCP). Unconditional logistic regression analysis was used to estimate the crude and adjusted odds ratios (ORs) and 95% confidential intervals (CI). Significant associations were found between maternal periconceptional FAS and decreased risk of NsCL/P (aOR = 0.41, 95% CI 0.33–0.51). This protective effect was also detected for NsCL (aOR = 0.42, 95% CI 0.30–0.58) and NsCLP (aOR = 0.41, 95% CI 0.31–0.54). Both maternal FAS started before and after the last menstrual period (LMP) were inversely associated with NsCL/P (before LMP, aOR = 0.43, 95% CI 0.33–0.56; after LMP, aOR = 0.41, 95% CI 0.33–0.51). The association between NsCP and maternal FAS initiating before LMP was also found (aOR = 0.52, 95% CI 0.30–0.90). The findings suggest that maternal periconceptional FAS can reduce the risk of each subtype of NsCL/P in offspring, while the potential effect on NsCP needs further investigations.
登录
查看更多内容
影响因子：
--
作者：
Carmichael, Suzan L.;Yang, Wei;Feldkamp, Marcia Lynn;Munger, Ronald G.;Siega-Riz, Anna Maria;Botto, Lorenzo D.;Shaw, Gary
通讯作者：
Shaw, Gary
中国西北陕西省最佳叶酸补充与出生缺陷关系的倾向匹配研究
影响因子：
4.6
作者：
Qu, Pengfei;Li, Shanshan;Dang, Shaonong
通讯作者：
Dang, Shaonong
影响因子：
13.6
作者：
Rozendaal, Anna M.;van Essen, Anthonie J.;de Walle, Hermien E. K.
通讯作者：
de Walle, Hermien E. K.
影响因子：
5.4
作者：
Li, Song;Chao, Ann;Berry, Robert J.
通讯作者：
Berry, Robert J.
DOI：
10.1159/000337464
发表时间：
2012-01-01
期刊：
CLEFT LIP AND PALATE: EPIDEMIOLOGY, AETIOLOGY AND TREATMENT
影响因子：
--
作者：
Mossey, P. A.;Modell, B.
通讯作者：
Modell, B.