Informatic resources for identifying and annotating structural RNA motifs.
Informatic resources for identifying and annotating structural RNA motifs.
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DOI：
10.1007/s12033-008-9114-z
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发表时间：
2009-02
影响因子：
2.6
通讯作者：
Tenenbaum SA
中科院分区：
文献类型：
--
作者：
George AD;Tenenbaum SA
Post-transcriptional regulation of genes and transcripts is a vital aspect of cellular processes, and unlike transcriptional regulation, remains a largely unexplored domain. One of the most obvious and most important questions to explore is the discovery of functional RNA elements. Many RNA elements have been characterized to date ranging from cis-regulatory motifs within mRNAs to large families of non-coding RNAs. Like protein coding genes, the functional motifs of these RNA elements are highly conserved, but unlike protein coding genes, it is most often structure and not sequence that conserved. Proper characterization of these structural RNA motifs is both the key and the limiting step to understanding the post-transcriptional aspects of the genomic world. Here we focus on the task of structural motif discovery and provide a survey of the informatics resources geared towards this task.
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