Neurochemical, hormonal, and behavioral effects of chronic unpredictable stress in the rat.
Neurochemical, hormonal, and behavioral effects of chronic unpredictable stress in the rat.
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DOI：
10.1016/j.bbr.2011.01.038
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发表时间：
2011-06-20
影响因子：
2.7
通讯作者：
Perrine, Shane A.
中科院分区：
文献类型：
--
作者：
Cox, Brittney M.;Alsawah, Fares;McNeill, Peter C.;Galloway, Matthew P.;Perrine, Shane A.
关键词：
焦虑和抑郁的高共患病率表明其病因可能具有一定程度的共同性。慢性不可预测的压力（CUS）模型有效地复制抑郁样表型，然而，CUS产生焦虑样行为的能力还没有得到充分的解决。在成年Sprague道利大鼠中使用CUS范例（每天2个应激源，持续10天），我们在停止治疗后一天确定了行为、激素和神经化学变化。在整个研究过程中，应激减弱了体重增加，并在给药后一天增加了自发活动，但通过高架十字迷宫测量，对焦虑行为没有影响。此外，血浆皮质酮水平与下丘脑5-羟色胺（5-HT）活性呈正相关，应激处理后一天，由代谢产物5-羟基吲哚乙酸（5-HIAA）与母体化合物的比例（5-HIAA/5-HT比）确定。这些数据表明与抑郁症相关的行为表型，而不是共病的焦虑，出现在停止压力后的立即时期，压力相关的生理学与下丘脑中的5-HT活性有关。
The high comorbidity of anxiety and depression suggests a potential degree of commonality in their etiologies. The chronic unpredictable stress (CUS) model effectively replicates depressive-like phenotypes; however, the ability of CUS to produce anxiety-like behaviors has not been adequately addressed. Using the CUS paradigm (2 stressors per day for 10 days) in adult Sprague Dawley rats we identified behavioral, hormonal, and neurochemical changes one day after the cessation of treatment. Stress attenuated weight gain throughout the study and increased locomotor activity one day after treatment, but had no effect on anxiety-behavior as measured by the elevated plus maze. In addition, plasma corticosterone levels were positively correlated with hypothalamic serotonin (5-HT) activity one day after stress treatment as determined by the ratio of the metabolite 5-hydroxyindoleacetic acid (5-HIAA) to the parent compound (5-HIAA/5-HT ratio). These data suggest behavioral phenotypes associated with depression, but not comorbid anxiety, emerge in the immediate period after cessation of stress and that stress related physiology is related to 5-HT activity in the hypothalamus.
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DOI：
10.1111/j.1532-5415.1987.tb02294.x
发表时间：
1987-10-01
影响因子：
6.3
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
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作者：
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