Hippocampal GluR1 associates with behavior in the elevated plus maze and shows sex differences.
Hippocampal GluR1 associates with behavior in the elevated plus maze and shows sex differences.
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DOI：
10.1016/j.bbr.2011.03.068
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发表时间：
2011-09-23
影响因子：
2.7
通讯作者：
Kosten, Therese A.
中科院分区：
文献类型：
--
作者：
Xiang, Xiaojun;Huang, Wen;Haile, Colin N.;Kosten, Therese A.
海马体与焦虑和空间记忆的形成有关，并且是两性异形的。雌性大鼠通常在高架十字迷宫程序（高架十字迷宫程序）中表现出较少的焦虑，这是一种标准的焦虑动物模型。海马中的许多细胞内蛋白质，包括α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体亚基GluR 1和环AMP反应元件结合蛋白（CREB），都参与记忆的形成。然而，海马GluR 1和CREB在焦虑中的作用知之甚少。我们检查了雄性和雌性大鼠海马的行为，并获得海马组织样本，用蛋白质印迹法测定GluR 1和CREB的水平。结果表明，雌性大鼠表现出较少的焦虑样行为比雄性大鼠。此外，行为在海马GluR 1水平显着相关，但不与CREB。然而，这两种蛋白质都显示出性别差异，雌性大鼠的水平较低。这些数据不仅表明了一些潜在的基础，海马体有助于行为的性别差异，但表明海马体GluR 1水平和焦虑之间有很强的关联，如评估与焦虑。
The hippocampus is involved in anxiety as well as spatial memory formation and is sexually dimorphic. Female rats typically show less anxiety in elevated plus maze procedure (EPM), a standard animal model of anxiety. Many intracellular proteins, including α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluR1 and the cyclic AMP response element-binding protein (CREB), in hippocampus contribute to memory formation. However, less is known about the roles for hippocampal GluR1 and CREB in anxiety. We examined behavior in EPM in male and female rats and obtained hippocampal tissue samples to determine levels of GluR1 and CREB with western blots. EPM results showed that female rats exhibited less anxiety-like behaviors than male rats. Further, behaviors in EPM were significantly correlated with hippocampal GluR1 levels, but not with CREB. Yet, both proteins showed sex differences with lower levels in female rats. These data not only suggest some potential bases for sex differences in behaviors to which the hippocampus contributes but demonstrate that there is a strong association between hippocampal GluR1 levels and anxiety as assessed with EPM.
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