Logic and lineage impacts on functional transcription factor deployment for T-cell fate commitment.
Logic and lineage impacts on functional transcription factor deployment for T-cell fate commitment.
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逻辑和谱系对T细胞命运承诺的功能转录因子部署的影响。
DOI：
10.1016/j.bpj.2021.04.002
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发表时间：
2021-10-05
影响因子：
3.4
通讯作者：
Rothenberg EV
中科院分区：
文献类型：
--
作者：
Rothenberg EV
转录因子是读取基因组中调控序列信息以启动特定基因表达变化的主要因子，无论是在发育过程中还是在生理激活反应中。它们的作用依赖于特定部位的DNA结合，并在很大程度上受到它们各自的DNA靶序列特异性的指导。然而，在真正的发育背景下，他们的行动比简单地读取局部基因组DNA序列要有更多的条件，这对有机体中的所有细胞来说都是常见的。它们受到染色质状态缓慢变化和与其他转录因子相互作用的限制，这些转录因子影响它们在整个基因组中潜在位置的占据模式。这些机制导致出现功能中断，即使是表达变化最小的转录因子也是如此。从造血干细胞发展而来的不同血细胞谱系很好地揭示了这一点，这些血细胞使用重叠的转录因子组合来驱动截然不同的基因调控程序。本文以造血多能祖细胞T淋巴细胞的发育为中心，综述了近年来有关结合特异性和动力学、转录因子的协同作用和染色质状态的变化如何影响PU.1、RUNX1、Notch-RBPJ和Bcl11b等关键转录因子的有效调节功能的最新证据。
Transcription factors are the major agents that read the regulatory sequence information in the genome to initiate changes in expression of specific genes, both in development and in physiological activation responses. Their actions depend on site-specific DNA binding and are largely guided by their individual DNA target sequence specificities. However, their action is far more conditional in a real developmental context than would be expected for simple reading of local genomic DNA sequence, which is common to all cells in the organism. They are constrained by slow-changing chromatin states and by interactions with other transcription factors, which affect their occupancy patterns of potential sites across the genome. These mechanisms lead to emergent discontinuities in function even for transcription factors with minimally changing expression. This is well revealed by diverse lineages of blood cells developing throughout life from hematopoietic stem cells, which use overlapping combinations of transcription factors to drive strongly divergent gene regulation programs. Here, using development of T lymphocytes from hematopoietic multipotent progenitor cells as a focus, recent evidence is reviewed on how binding specificity and dynamics, transcription factor cooperativity, and chromatin state changes impact the effective regulatory functions of key transcription factors including PU.1, Runx1, Notch-RBPJ, and Bcl11b.
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影响因子：
4
作者：
Apostolou E;Stadtfeld M
通讯作者：
Stadtfeld M
DOI：
10.1126/science.1162327
发表时间：
2009-06-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Badis G;Berger MF;Philippakis AA;Talukder S;Gehrke AR;Jaeger SA;Chan ET;Metzler G;Vedenko A;Chen X;Kuznetsov H;Wang CF;Coburn D;Newburger DE;Morris Q;Hughes TR;Bulyk ML
通讯作者：
Bulyk ML
在单细胞水平上表观遗传调节的动力学。
DOI：
10.1126/science.aab2956
发表时间：
2016-02-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bintu L;Yong J;Antebi YE;McCue K;Kazuki Y;Uno N;Oshimura M;Elowitz MB
通讯作者：
Elowitz MB
影响因子：
10.5
作者：
Champhekar A;Damle SS;Freedman G;Carotta S;Nutt SL;Rothenberg EV
通讯作者：
Rothenberg EV
影响因子：
7.3
作者：
Bevington SL;Cauchy P;Withers DR;Lane PJ;Cockerill PN
通讯作者：
Cockerill PN