COVID-19 Crisis Creates Opportunity towards Global Monitoring & Surveillance.

COVID-19 Crisis Creates Opportunity towards Global Monitoring & Surveillance.
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DOI:
10.3390/pathogens10030256
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发表时间:
2021-02-24
期刊:
Pathogens (Basel, Switzerland)
影响因子:
--
通讯作者:
Bokhari H
Bokhari H
中科院分区:
其他
文献类型:
--
作者:
Donia A;Hassan SU;Zhang X;Al-Madboly L;Bokhari H

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新出现的疾病以及重新出现的旧疾病的范围正在扩大,因为传染性病原体为了应对不断变化的生态系统而以巨大的速度进化、适应和传播。严重急性呼吸系统综合征冠状病毒2(SARS-CoV-2)是一种最近的现象,可能需要一段时间才能了解其从较少旅行地区的传播途径,从污染物暴露途径到废水传播。关键的挑战是如何在全球总人口约为80亿的高收入国家(高收入国家约占全球人口的20%)和中低收入国家(低收入国家约占全球人口的80%)与这种灾难性的流行病进行谈判,在这些国家,实际的大规模检测和追踪只是一个遥远的可能性,特别是在中低收入国家。考虑到近年来高收入国家(HIC)和中低收入国家(LMIC)的人口分布差异以及城市化趋势,传统的基于废水的监测(如用于防治脊髓灰质炎的监测)可能有助于应对这一挑战。COVID-19时代与以往任何大流行病或全球健康挑战都不同,因为全球社会都有很大的好奇心,想了解有关这种病毒的一切,从诊断方法、潜在的疫苗/治疗方法到可能的传播途径。在这方面,肠道是脊髓灰质炎病毒和SARS-CoV-2的共同生存环境,而且由于病毒通过粪便物质进入下水道系统,因此越来越明显地需要长期的废水监测和发展预警系统,以便在地方和全球各级更好地做好准备。本文旨在深入了解持续的COVID-19危机,如何管理它,以及需要采取哪些措施来应对当前的全球国际公共卫生问题。此外,它阐明了使用废水监测策略作为适用于大规模被动筛选的预警实用工具的重要性,以及迫切需要微流体技术作为一种快速和具有成本效益的方法来跟踪废水中的SARS-CoV-2。
The spectrum of emerging new diseases as well as re-emerging old diseases is broadening as infectious agents evolve, adapt, and spread at enormous speeds in response to changing ecosystems. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recent phenomenon and may take a while to understand its transmission routes from less traveled territories, ranging from fomite exposure routes to wastewater transmission. The critical challenge is how to negotiate with such catastrophic pandemics in high-income countries (HICs ~20% of the global population) and low-and middle-income countries (LMICs ~ 80% of the global population) with a total global population size of approximately eight billion, where practical mass testing and tracing is only a remote possibility, particularly in low-and middle-income countries (LMICs). Keeping in mind the population distribution disparities of high-income countries (HICs) and LMICs and urbanisation trends over recent years, traditional wastewater-based surveillance such as that used to combat polio may help in addressing this challenge. The COVID-19 era differs from any previous pandemics or global health challenges in the sense that there is a great deal of curiosity within the global community to find out everything about this virus, ranging from diagnostics, potential vaccines/therapeutics, and possible routes of transmission. In this regard, the fact that the gut is the common niche for both poliovirus and SARS-CoV-2, and due to the shedding of the virus through faecal material into sewerage systems, the need for long-term wastewater surveillance and developing early warning systems for better preparedness at local and global levels is increasingly apparent. This paper aims to provide an insight into the ongoing COVID-19 crisis, how it can be managed, and what measures are required to deal with a current global international public health concern. Additionally, it shed light on the importance of using wastewater surveillance strategy as an early warning practical tool suitable for massive passive screening, as well as the urgent need for microfluidic technology as a rapid and cost-effective approach tracking SARS-CoV-2 in wastewater.
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发表时间: 2020-09-15
影响因子: 11.1
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