Edited magnetic resonance spectroscopy in the neonatal brain.

Edited magnetic resonance spectroscopy in the neonatal brain.
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编辑了新生儿大脑的磁共振波谱。

DOI:
10.1007/s00234-021-02821-9
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发表时间:
2022-03
期刊:
影响因子:
2.8
通讯作者:
Edden RAE
Edden RAE
中科院分区:
医学3区
文献类型:
--
作者:
Song Y;Lally PJ;Yanez Lopez M;Oeltzschner G;Nebel MB;Gagoski B;Kecskemeti S;Hui SCN;Zöllner HJ;Shukla D;Arichi T;De Vita E;Yedavalli V;Thayyil S;Fallin D;Dean DC 3rd;Grant PE;Wisnowski JL;Edden RAE

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J-差分编辑波谱法是一种利用磁共振波谱(MRS)检测低浓度代谢物的有价值的方法。目前,由于次优信噪比、相对较长的采集时间和易受运动伪影影响,很少在新生儿中进行编辑的MRS研究。尽管如此,这项技术在儿科成像研究中提供了一个令人兴奋的机会,可以研究出生后早期神经递质系统和其他代谢系统的快速成熟变化。研究这些代谢过程对于了解生命最初几年发生的广泛而快速的结构和功能变化至关重要。本综述的总体目标是介绍新生儿编辑的MRS,包括编辑方法和可编辑代谢物的当前最新技术水平,并回顾将编辑的MRS应用于新生儿大脑的当前文献。现有的挑战和未来的机遇,包括缺乏特定年龄的参考数据,也进行了讨论。
J-difference-edited spectroscopy is a valuable approach for the detection of low-concentration metabolites with magnetic resonance spectroscopy (MRS). Currently, few edited MRS studies are performed in neonates due to suboptimal signal-to-noise ratio, relatively long acquisition times, and vulnerability to motion artifacts. Nonetheless, the technique presents an exciting opportunity in pediatric imaging research to study rapid maturational changes of neurotransmitter systems and other metabolic systems in early postnatal life. Studying these metabolic processes is vital to understanding the widespread and rapid structural and functional changes that occur in the first years of life. The overarching goal of this review is to provide an introduction to edited MRS for neonates, including the current state-of-the-art in editing methods and editable metabolites, as well as to review the current literature applying edited MRS to the neonatal brain. Existing challenges and future opportunities, including the lack of age-specific reference data, are also discussed.
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