There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia.

There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia.
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DOI:
10.1007/s11845-021-02545-y
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发表时间:
2022-03
影响因子:
2.1
通讯作者:
Kelly C
Kelly C
中科院分区:
医学4区
文献类型:
--
作者:
Williamson J;Black L;Black A;Koduri G;Kelly C

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covid-19肺炎的临床表现与某些风湿病中的急性间质性肺疾病有相当多的重叠。此外,肺纤维化越来越被认为是这两种疾病的潜在严重后果。这篇综述探讨了这种重叠的临床特征、危险因素和病因,提供了对导致这两种疾病的免疫机制的见解。由此说明免疫抑制和生物制剂在新冠肺炎治疗中的作用。我们提出了如何从最近对每种疾病的见解中吸取教训,以提高我们对其他疾病的免疫机制和治疗干预应用的认识。
There is considerable overlap between the clinical manifestations of covid-19 pneumonia and the acute interstitial lung disease seen in certain rheumatic disorders. In addition, pulmonary fibrosis is increasingly recognised as a potentially serious consequence of both. This review explores this overlap of clinical features, risk factors and causation, offering insights into the immune mechanisms that contribute to both sets of disorders. The therapeutic role of immunosuppression and biologic agents in the treatment of covid-19 is explained in the light of this. We propose how lessons learned from the insights recently gained into each disorder can improve our insight into immunological mechanisms and application of therapeutic interventions in the other.
DOI: 10.1056/nejmoa2022926
发表时间: 2020-11-19
期刊: The New England journal of medicine
影响因子: --
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