Incidence and mortality of interstitial lung disease in rheumatoid arthritis: a population-based study.
Incidence and mortality of interstitial lung disease in rheumatoid arthritis: a population-based study.
复制标题
类风湿性关节炎间质性肺疾病的发病率和死亡率：一项基于人群的研究。
DOI：
10.1002/art.27405
复制
发表时间：
2010-06
影响因子：
--
通讯作者：
Matteson, Eric L.
中科院分区：
文献类型：
--
作者：
Bongartz, Tim;Nannini, Carlotta;Medina-Velasquez, Yimy F.;Achenbach, Sara J.;Crowson, Cynthia S.;Ryu, Jay H.;Vassallo, Robert;Gabriel, Sherine E.;Matteson, Eric L.
间质性肺疾病（ILD）已被认为是类风湿关节炎（RA）的重要合并症。我们的目的是评估RA相关ILD的发病率、危险因素和死亡率。我们研究了一个以人群为基础的类风湿关节炎发病率队列和一个匹配的非类风湿关节炎个体队列。对所有受试者进行纵向随访，直至死亡、迁移或2006年1月1日。估计ILD的终生风险，并使用考克斯模型比较队列间ILD的发生率，研究可能的风险因素并探索ILD对患者生存期的影响。对582例RA患者和603例非RA受试者分别进行了平均16.4年和19.3年的随访。RA患者发生ILD的终生风险为7.7%，非RA受试者为0.9%。该差异转化为风险比为8.96（95% CI 4.02，19.94）。在RA发作时年龄较大的患者中，男性患者和参数指示更严重RA的个体发生ILD的风险更高。诊断为ILD的RA患者的生存率低于无ILD的RA患者（HR 2.86，95% CI 1.98，4.12）。与一般人群相比，ILD约占RA患者死亡率的13%。我们的研究结果强调RA患者ILD的风险增加。ILD对患者生存的影响提供了证据，表明制定更好的ILD治疗策略可以显着降低RA患者的超额死亡率。
Interstitial lung disease (ILD) has been recognized as an important co-morbidity in rheumatoid arthritis (RA). We aimed to assess incidence, risk factors and mortality of RA associated ILD. We examined a population-based incidence cohort of patients with RA and a matched cohort of individuals without RA. All subjects were followed longitudinally until death, migration or January 1, 2006. The lifetime risk of ILD was estimated and Cox models were used to compare the incidence of ILD between cohorts, to investigate possible risk factors and to explore the impact of ILD on patient survival. 582 patients with RA and 603 subjects without RA were followed for a mean of 16.4 and 19.3 years, respectively. The lifetime risk of developing ILD was 7.7% for RA patients and 0.9% for subjects without RA. This difference translated into a hazard ratio of 8.96 (95% CI 4.02, 19.94). The risk of developing ILD was higher in patients with older age at RA onset, among male patients and for individuals with parameters that indicate more severe RA. Survival of RA patients diagnosed with ILD was worse compared to RA patients without ILD (HR 2.86, 95% CI 1.98, 4.12). ILD contributed approximately 13% to the excess mortality of patients with RA patients when compared to the general population. Our results emphasize the increased risk of ILD in patients with RA. The impact of ILD on patient survival provides evidence that development of better strategies for the treatment of ILD could significantly lower the excess mortality of individuals with RA.
登录
查看更多内容
影响因子：
27.4
作者：
Carmona, L;González-Alvaro, I;Sanmartí, R
通讯作者：
Sanmartí, R
影响因子：
--
作者：
Saag, KG;Kolluri, S;Schwartz, DA
通讯作者：
Schwartz, DA
影响因子：
--
作者：
Doran, MF;Pond, GR;Gabriel, SE
通讯作者：
Gabriel, SE
影响因子：
27.4
作者：
Turesson, C;O'Fallon, WM;Matteson, EL
通讯作者：
Matteson, EL
影响因子：
--
作者：
Gabriel, SE;Crowson, CS;Matteson, EL
通讯作者：
Matteson, EL