Red blood cell lithium-sodium countertransport in the tecumseh blood pressure study.
Red blood cell lithium-sodium countertransport in the tecumseh blood pressure study.
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tecumseh 血压研究中的红细胞锂钠反转运。
DOI：
10.1161/01.hyp.17.5.652
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Julius,S
中科院分区：
文献类型：
--
作者：
Weder,AB;Schork,NJ;Krause,L;Julius,S
人类原发性高血压有不止一种原因，但要剖析亚型，需要标记物。病例对照和基于人群的研究表明，高血压患者红细胞锂钠反转运的最大活性有所增加；在后者中，其分布是两个重叠但可区分的亚群的混合。在本研究中，我们将 Tecumseh 血压研究的 705 名参与者分为正常（平均 0.234 mmol/l 细胞/小时；n = 614）或高（平均 0.463 mmol/l 细胞/小时；n = 91）红细胞锂钠反转运，以确定红细胞标志物是否与独特的生理特征相关。我们发现，与逆转运正常的受试者相比，锂钠逆转运升高的受试者平均血压更高，高血压患病率更高，并且血压升高从青年时期就存在。从血流动力学角度来看，高反转运组的特点是血管阻力升高，而交感神经系统活动似乎略有下降。与反转运正常的受试者相比，锂钠反转运增加的受试者的平均左心室质量指数显着较低，并且很少表现出左心室肥厚。我们的结果支持测量红细胞锂钠反转运最大活性作为区分人群亚组的一种方法是有用的。我们的数据与以下观点一致：红细胞锂钠反转运最大活性升高的受试者是具有遗传病变的人群的一个子集，该病变使他们容易患上原发性高血压。
Human essential hypertension has more than one cause, but to dissect out subtypes, markers are required. The maximal activity of red blood cell lithium-sodium countertransport has been shown to be increased in hypertensive patients in case-control and population-based studies; in the latter, its distribution is a mixture of two overlapping but distinguishable subpopulations. In the present study, we classified 705 participants in the Tecumseh Blood Pressure Study as having either normal (mean, 0.234 mmol/l cells/hr; n = 614) or high (mean, 0.463 mmol/l cells/hr; n = 91) red blood cell lithium-sodium countertransport to determine if the red blood cell marker is associated with distinctive physiological characteristics. We found that subjects with elevated lithium-sodium countertransport have higher average blood pressure and a greater prevalence of hypertension than those with normal countertransport and that elevated blood pressure had been present since youth. Hemodynamically, the high countertransport group is characterized by elevated vascular resistance, whereas sympathetic nervous system activity appears to be slightly depressed. Subjects with increased lithium-sodium countertransport, compared with those with normal countertransport, have significantly lower average left ventricular mass index and only very infrequently demonstrate left ventricular hypertrophy. Our results support the usefulness of measurements of the maximal activity of red blood cell lithium-sodium countertransport as a way of distinguishing subgroups in the population. Our data are consistent with the idea that subjects with an elevated maximal activity for red blood cell lithium-sodium countertransport are a subset of the population with a genetic lesion that predisposes them to the development of essential hypertension.
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红细胞阳离子转运的种族差异。
影响因子：
8.3
作者：
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影响因子：
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作者：
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影响因子：
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作者：
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一个原因？许多原因？来自双峰分布的论证。
DOI：
--
发表时间：
1964
期刊：
Journal of Chronic Diseases
影响因子：
--
作者：
E. Murphy
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影响因子：
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作者：
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