Combined Treatment with an Anticoagulant and a Vasodilator Prevents Steroid-Associated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability.
Combined Treatment with an Anticoagulant and a Vasodilator Prevents Steroid-Associated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability.
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抗凝剂和血管扩张剂联合治疗通过改善高凝状态来预防类固醇相关的兔股骨头坏死
DOI：
10.1155/2017/1624074
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发表时间：
2017
影响因子：
--
通讯作者：
Zhao D
中科院分区：
文献类型：
--
作者：
Cao F;Liu G;Wang W;Wang B;Wei X;Lu F;Yang F;Kang K;Wang Y;Yang J;Qin K;Zhao D
激素相关性股骨头坏死仍然是世界范围内骨科的一个具有挑战性的问题。一种病理机制是由于血栓形成和血管收缩导致的股骨头缺血。本研究探讨依诺肝素和EGb 761联合预防对兔激素相关性ONFH的影响。将家兔随机分为5组（对照组、模型组、依诺肝素组、银杏叶组、联合组）。除对照组外，其余各组均采用脂多糖和醋酸甲泼尼龙造模。模型建立后，依诺肝素组和银杏对照组分别给予依诺肝素1 μg/kg/d皮下注射和EGb 761 40 mg/kg/d口服，连续4周;联合用药组同时给予两种药物治疗。造模6周后，血液学数据显示三个预防组的PT和APTT延长。显微CT检查显示骨密度较高，结构较好;组织形态计量学显示明显的病理改变。免疫组化显示BMP-2和VEGF的表达更高，从而揭示了更好的成骨和血管生成活性。在三个预防组中，联合组的效果最好。总之，抗凝剂和血管扩张剂的联合预防有可能降低兔类固醇相关ONFH的发生率。
Steroid-associated osteonecrosis of the femoral head remains a challenging problem in orthopedics worldwide. One pathomechanism is ischemia of the femoral head, as a result of thrombus formation and vasoconstriction. The present study investigates the effects of combination prevention with enoxaparin and EGb 761 on steroid-associated ONFH in rabbits. Rabbits were randomly divided into 5 groups (control group, model group, enoxaparin group, ginkgo group, and combination group). With the exception of the control group, the groups of rabbits were modeled with lipopolysaccharide and methylprednisolone acetate. Starting with modeling, the enoxaparin group and ginkgo group were injected with 1 μg/kg/day enoxaparin subcutaneously and orally given 40 mg/kg/day EGb 761 for 4 weeks, respectively; the combination group received both treatments. After modeling for 6 weeks, the hematology data indicated prolonged PT and APTT in the three prevention groups. The micro-CT examination revealed higher bone density and better structure; histomorphometry revealed significant pathological changes. Immunohistochemistry revealed higher expression of BMP-2 and VEGF, thus revealing better osteogenesis and angiogenesis activities. Among the three prevention groups, the combination group had the most efficient results. In conclusion, the combined prevention with an anticoagulant and a vasodilator has the potential to decrease the incidence of steroid-associated ONFH in rabbits.
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DOI：
10.1161/circoutcomes.109.871640
发表时间：
2010-01
期刊：
Circulation. Cardiovascular quality and outcomes
影响因子：
--
作者：
Kuller LH;Ives DG;Fitzpatrick AL;Carlson MC;Mercado C;Lopez OL;Burke GL;Furberg CD;DeKosky ST;Ginkgo Evaluation of Memory Study Investigators
通讯作者：
Ginkgo Evaluation of Memory Study Investigators
影响因子：
--
作者：
Beckmann, Rainer;Shaheen, Hayfaa;Drescher, Andwolf
通讯作者：
Drescher, Andwolf
DOI：
10.2174/1874325001206010449
发表时间：
2012-01-01
期刊：
The open orthopaedics journal
影响因子：
--
作者：
Chan, K L;Mok, C C
通讯作者：
Mok, C C
DOI：
10.1097/01.blo.0000127587.92303.b4
发表时间：
2004-06-01
影响因子：
4.2
作者：
Drescher, W;Bünger, MH;Hansen, ES
通讯作者：
Hansen, ES
影响因子：
6.1
作者：
Kuboto, Y;Tanaka, N;Kunitomo, M
通讯作者：
Kunitomo, M