Non-Coding RNAs Regulate Spinal Cord Injury-Related Neuropathic Pain via Neuroinflammation.
Non-Coding RNAs Regulate Spinal Cord Injury-Related Neuropathic Pain via Neuroinflammation.
复制标题
非编码RNA通过神经炎症调节脊髓损伤相关的神经病理性疼痛。
DOI：
10.2147/jir.s413264
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发表时间：
2023
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
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作者：
继发性慢性神经性疼痛（NP）除了感觉，运动，或自主神经功能障碍可以显着降低生活质量脊髓损伤（SCI）后。SCI相关NP的机制已在临床试验和使用实验模型中进行了研究。然而，在为SCI患者开发新的治疗策略时，NP提出了新的挑战。SCI后的炎症反应促进了NP的发展。先前的研究表明，减少SCI后的神经炎症可以改善NP相关行为。对非编码RNA在SCI中作用的深入研究发现，ncRNA结合靶mRNA，作用于活化的胶质细胞、神经元细胞或其他免疫细胞，调节基因表达，抑制炎症，并影响NP的预后。
Secondary chronic neuropathic pain (NP) in addition to sensory, motor, or autonomic dysfunction can significantly reduce quality of life after spinal cord injury (SCI). The mechanisms of SCI-related NP have been studied in clinical trials and with the use of experimental models. However, in developing new treatment strategies for SCI patients, NP poses new challenges. The inflammatory response following SCI promotes the development of NP. Previous studies suggest that reducing neuroinflammation following SCI can improve NP-related behaviors. Intensive studies of the roles of non-coding RNAs in SCI have discovered that ncRNAs bind target mRNA, act between activated glia, neuronal cells, or other immunocytes, regulate gene expression, inhibit inflammation, and influence the prognosis of NP.
影响因子：
4.2
作者：
Zheng SR;Guo GL;Zhang W;Huang GL;Hu XQ;Zhu J;Huang QD;You J;Zhang XH
通讯作者：
Zhang XH