Evolutionary perspective on mammalian inorganic polyphosphate (polyP) biology.
Evolutionary perspective on mammalian inorganic polyphosphate (polyP) biology.
复制标题
DOI：
10.1042/bst20230483
复制
发表时间：
2023-10-31
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
无机聚磷酸盐（polyP）是磷酸盐的聚合形式，由于其在哺乳动物细胞内的许多功能而引起越来越多的关注。这篇文章并不旨在系统地回顾丰富的哺乳动物息肉文献。相反，我们研究了polyP在各种微生物中的合成和功能，并使用进化的观点来理论化该领域的关键问题并提出解决方案。通过强调VTC4在非常不同的真核生物分支（Opisthokonta, Viridiplantae， Discoba和SAR）的不同物种中的存在，我们提出，虽然息肉合成机制存在于祖先真核生物中，但大多数谱系随后在进化过程中失去了它。对细菌获得的变形虫PPK1及其独特的息肉生理的分析表明，真核细胞必须发展出限制胞质息肉积累的机制。我们从细菌内共生起源的角度回顾了线粒体中息肉的文献，强调了线粒体如何能够拥有息肉生理学，这让人想起它们的“细菌”起源，但尚未被研究。最后，我们强调了阴离子息肉p与更好理解的带负电荷的聚合物DNA和RNA的相似之处，假设细胞核提供了一个理想的环境，息肉p生理学可能会茁壮成长。
Inorganic polyphosphate (polyP), the polymeric form of phosphate, is attracting ever-growing attention due to the many functions it appears to perform within mammalian cells. This essay does not aim to systematically review the copious mammalian polyP literature. Instead, we examined polyP synthesis and functions in various microorganisms and used an evolutionary perspective to theorise key issues of this field and propose solutions. By highlighting the presence of VTC4 in distinct species of very divergent eucaryote clades (Opisthokonta, Viridiplantae, Discoba, and the SAR), we propose that whilst polyP synthesising machinery was present in the ancestral eukaryote, most lineages subsequently lost it during evolution. The analysis of the bacteria-acquired amoeba PPK1 and its unique polyP physiology suggests that eukaryote cells must have developed mechanisms to limit cytosolic polyP accumulation. We reviewed the literature on polyP in the mitochondria from the perspective of its endosymbiotic origin from bacteria, highlighting how mitochondria could possess a polyP physiology reminiscent of their ‘bacterial’ beginning that is not yet investigated. Finally, we emphasised the similarities that the anionic polyP shares with the better-understood negatively charged polymers DNA and RNA, postulating that the nucleus offers an ideal environment where polyP physiology might thrive.
影响因子：
6.4
作者：
Zencheck WD;Xiao H;Weiss LM
通讯作者：
Weiss LM
影响因子：
6.4
作者：
通讯作者：
--
影响因子：
5.6
作者：
Rijal, Ramesh;Ismail, Issam;Jing, Shiyu;Gomer, Richard H.
通讯作者：
Gomer, Richard H.