Lysine post-translational modifications and the cytoskeleton.
Lysine post-translational modifications and the cytoskeleton.
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DOI：
10.1042/bse0520135
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发表时间：
2012
影响因子：
6.4
通讯作者：
Weiss LM
中科院分区：
文献类型：
--
作者：
Zencheck WD;Xiao H;Weiss LM
赖氨酸残基的 PTM（翻译后修饰）已被证明是基因表达、蛋白质-蛋白质相互作用以及蛋白质加工和降解的主要调节因子。这对于调节细胞骨架特别重要，细胞骨架是一个极其复杂的蛋白质系统，负责细胞运动、细胞内运输以及细胞形式和结构的维持。细胞骨架存在于所有细胞中，包括真核生物和原核生物，并包含鞭毛、纤毛和片状伪足等结构，它们在细胞内运输和细胞分裂中发挥关键作用。细胞骨架调节依赖于众多的多组分组件。在本章中，我们重点关注通过细胞骨架亚基及其辅助蛋白上赖氨酸残基的 PTM 来调节细胞骨架。我们特别关注真核生物中聚合成丝的三类主要细胞骨架蛋白，包括微丝（肌动蛋白丝）、中间丝和微管。我们讨论了赖氨酸乙酰化的鉴定和生物学重要性，赖氨酸乙酰化是所有三种丝类型的调节剂。我们还回顾了其他赖氨酸修饰，例如泛素化和 SUMOylation，及其在蛋白质调节和加工中的作用。
PTMs (post-translational modifications) of lysine residues have proven to be major regulators of gene expression, protein–protein interactions, and protein processing and degradation. This is of particular importance in regulating the cytoskeleton, an enormously complex system of proteins responsible for cell motility, intracellular trafficking, and maintenance of cell form and structure. The cytoskeleton is present in all cells, including eukaryotes and prokaryotes, and comprises structures such as flagella, cilia and lamellipodia which play critical roles in intracellular transport and cellular division. Cytoskeletal regulation relies on numerous multi-component assemblies. In this chapter, we focus on the regulation of the cytoskeleton by means of PTMs of lysine residues on the cytoskeletal subunits and their accessory proteins. We specifically address the three main classes of cytoskeletal proteins in eukaryotes that polymerize into filaments, including microfilaments (actin filaments), intermediate filaments and microtubules. We discuss the identification and biological importance of lysine acetylation, a regulator of all three filament types. We also review additional lysine modifications, such as ubiquitination and SUMOylation, and their role in protein regulation and processing.
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影响因子：
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