Accurate In Vivo Bowman's Thickness Measurement Using Mirau Ultrahigh Axial Resolution Line Field Optical Coherence Tomography.
Accurate In Vivo Bowman's Thickness Measurement Using Mirau Ultrahigh Axial Resolution Line Field Optical Coherence Tomography.
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DOI：
10.1167/tvst.11.8.6
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发表时间：
2022-08-01
影响因子：
3
通讯作者：
Zheng, Yalin
中科院分区：
文献类型：
--
作者：
Lawman, Samuel;Mason, Sharon;Kaye, Stephen B.;Shen, Yao-Chun;Zheng, Yalin
关键词：
本研究的目的是评估体内 Mirau 超高轴向分辨率 (UHR) 线场谱域 (LF-SD) 光学相干断层扫描 (OCT) 用于测量鲍曼和上皮厚度的准确性、重复性和性能限制，并为健康角膜提供这些值的参考范围。本研究纳入了没有角膜疾病病史和证据的志愿者。在法向界面矢量方向获得中央角膜的体内图搜索图像分割。所使用的 Mirau-UHR-LF-SD-OCT 系统的轴向分辨率在空气中低至 2.4 µm（在组织中为 1.7 µm），A 扫描速度为 204.8 kHz，信噪比（灵敏度）为 69 (83) dB。其中包括九名志愿者，其中一名戴着隐形眼镜。平均鲍曼厚度和上皮厚度的重复性分别为 0.3 和 1.0 µm。测得的 95% 群体健康体内厚度范围为：鲍曼层厚度为 13.7 至 19.6 µm，上皮层厚度为 41.9 至 61.8 µm。使用 Mirau-UHR-LF-SD-OCT 测量的鲍曼层和角膜上皮的厚度都很准确，健康体内厚度的范围与先前不同轴向分辨率的共焦和 OCT 系统相匹配，并且可重复，等于先前报道的最佳值。 T1。开发商业上可行的临床 UHR OCT 技术，能够在临床实践中准确测量和解释鲍曼层和上皮层厚度。
The purpose of this study was to assess the accuracy, repeatability, and performance limits of in vivo Mirau ultrahigh axial resolution (UHR) line field spectral domain (LF-SD) optical coherence tomography (OCT) for the measurement of Bowman's and epithelial thickness, and to provide a reference range of these values for healthy corneas. Volunteers with no history and evidence of corneal disease were included in this study. An in vivo graph search image segmentation of the central cornea was obtained at the normal interface vector orientation. The Mirau-UHR-LF-SD-OCT system used has an axial resolution down to 2.4 µm in air (1.7 µm in tissue), with an A-scan speed of 204.8 kHz and a signal to noise ratio (sensitivity) of 69 (83) dB. Nine volunteers were included, one of whom wore contact lenses. The repeatability of mean Bowman's and epithelial thicknesses were 0.3 and 1.0 µm, respectively. The measured 95% population range for healthy in vivo thickness was 13.7 to 19.6 µm for the Bowman's layer, and 41.9 to 61.8 µm for the epithelial layer. The measured thicknesses of Bowman's layer and the corneal epithelium using the Mirau-UHR-LF-SD-OCT were both accurate, with the range for healthy in vivo thicknesses matching prior confocal and OCT systems of varying axial resolutions, and repeatable, equaling the best value prior reported. T1. Development of a commercially viable clinical UHR OCT technology, enabling accurate measurement and interpretation of Bowman's and epithelial layer thickness in clinical practice.
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影响因子：
2
作者：
Li, HF;Petroll, WM;Jester, JV
通讯作者：
Jester, JV
影响因子：
13.7
作者：
Li Y;Tan O;Brass R;Weiss JL;Huang D
通讯作者：
Huang D
影响因子：
13.7
作者：
Kobayashi, Akira;Yokogawa, Hideaki;Sugiyama, Kazuhisa
通讯作者：
Sugiyama, Kazuhisa
亚鲍曼角膜磨镶术 (SBK) 角膜瓣制作方法对鲍曼层中央厚度的影响
影响因子：
3.7
作者：
Xu Z;Shen M;Hu L;Zhuang X;Peng M;Hu D;Liu J;Wang J;Qu J;Lu F
通讯作者：
Lu F
影响因子：
2.4
作者：
Hu, Liang;Li, Yong;Lu, Fan
通讯作者：
Lu, Fan