The Impact of Flap Creation Methods for Sub-Bowman's Keratomileusis (SBK) on the Central Thickness of Bowman's Layer.
The Impact of Flap Creation Methods for Sub-Bowman's Keratomileusis (SBK) on the Central Thickness of Bowman's Layer.
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亚鲍曼角膜磨镶术 (SBK) 角膜瓣制作方法对鲍曼层中央厚度的影响
DOI：
10.1371/journal.pone.0124996
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Lu F
中科院分区：
文献类型：
--
作者：
Xu Z;Shen M;Hu L;Zhuang X;Peng M;Hu D;Liu J;Wang J;Qu J;Lu F
确定Bowman下角膜磨镶术（SBK）的角膜瓣制作方法对中央Bowman层厚度的影响。20例受试者采用Moria微型角膜刀制作SBK瓣，21例受试者采用飞秒（FEMTO）激光制作SBK瓣。在SBK前和SBK后1天、1周、2周和1个月，通过超高分辨率光学相干断层扫描仪测量角膜亚层厚度。每例受试者在每次访视时接受两次成像。使用定制的自动图像处理算法计算中央上皮、Bowman层、瓣和总角膜的厚度。在SBK后1周，通过组内相关系数（ICC）和重复性系数（CoR）测试亚层厚度测量的重复性。Moria组和FEMTO组所有亚层测量的ICC分别≥0.959和≥0.961。分割CoR分别小于6.78%和5.63%。对于这两个组，在SKB后，上皮和Bowman层中存在微变形。术后第1天Moria组皮瓣厚度比FEMTO组薄9.8 μm（95%可信区间：4.8 ~ 14.8μm）（独立样本t检验，P < 0.05）。术后第1天Moria组和FEMTO组Bowman层分别增厚1.6 ± 1.1 μm和1.7 ± 1.6 μm（重复方差分析，P < 0.05），之后趋于稳定。两组之间的角膜和亚层厚度相似。SBK后1天中央Bowman层厚度增加。Moria微型角膜刀和飞秒激光的角膜瓣创建对SBK后Bowman层厚度没有显著不同的影响。中国临床试验注册中心（ChiCTR）编号：ChiCTR-OCH-14004525
To determine the impact of flap creation methods for sub-Bowman’s keratomileusis (SBK) on central Bowman’s layer thickness. SBK flaps were made by Moria microkeratome for 20 subjects and by femtosecond (FEMTO) laser for 21 subjects. Corneal sublayer thicknesses were measured by ultra-high resolution optical coherence tomography before SBK and at 1 day, 1 week, 2 weeks, and 1 month afterwards. Each subject was imaged twice on each visit. Thicknesses of central epithelium, Bowman’s layer, flap, and total cornea were calculated using a custom-made automated image processing algorithm. The repeatability of sublayer thickness measurements was tested by the intraclass correlation coefficient (ICC) and by the coefficient of repeatability (CoR) at 1 week post-SBK. ICCs of the Moria and FEMTO groups were ≥0.959 and ≥0.961 respectively for all sublayer measurements. The segmentation CoRs were less than 6.78% and 5.63% respectively. For both groups, microdistortions were present in the epithelium and Bowman’s layer after SKB. The flap thickness of the Moria group was 9.8 μm (95% confidence interval: 4.8 – 14.8μm) thinner than the FEMTO group one day after SBK (independent samples t-test, P < 0.05). Bowman’s layer became thicker by 1.6 ± 1.1 μm and 1.7 ± 1.6 μm one day post-SBK for the Moria and FEMTO groups (repeated ANOVA, P < 0.05) and then remained stable. Corneal and sublayer thickness were similar between the two groups. Central Bowman’s layer thickness increased 1 day post-SBK. Flap creation by Moria microkeratome and femtosecond laser did not have significantly different impacts on Bowman’s layer thickness following SBK. Chinese Clinical Trial Registry (ChiCTR) NO: ChiCTR-OCH-14004525
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影响因子：
2.8
作者：
Binder, Perry S.
通讯作者：
Binder, Perry S.
影响因子：
4.4
作者：
Ge, Lili;Yuan, Yimin;Lu, Fan
通讯作者：
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影响因子：
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作者：
Charman, WN
通讯作者：
Charman, WN
影响因子：
2.2
作者：
Hamilton, Cody;Lewis, Steven
通讯作者：
Lewis, Steven
影响因子：
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作者：
Krueger, Ronald R.;Rabinowitz, Yaron S.;Binder, Perry S.
通讯作者：
Binder, Perry S.