Bone-targeted erythrocyte-cancer hybrid membrane-camouflaged nanoparticles for enhancing photothermal and hypoxia-activated chemotherapy of bone invasion by OSCC.
Bone-targeted erythrocyte-cancer hybrid membrane-camouflaged nanoparticles for enhancing photothermal and hypoxia-activated chemotherapy of bone invasion by OSCC.
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骨靶向的红细胞癌杂种杂交膜膜纳米颗粒，以增强OSCC对骨侵袭的光热和缺氧的化学疗法。
DOI：
10.1186/s12951-021-01088-9
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发表时间：
2021-10-26
影响因子：
10.2
通讯作者：
Dai H
中科院分区：
文献类型：
--
作者：
Chen H;Deng J;Yao X;He Y;Li H;Jian Z;Tang Y;Zhang X;Zhang J;Dai H
颌骨因其特殊的解剖关系，是口腔恶性肿瘤如口腔鳞状细胞癌（oral squamous cell carcinoma，OSCC）最常侵犯的器官。各种严重并发症，如病理性骨折和骨痛，可显著降低患者的生活质量甚至生存结局。虽然化疗是一种很有前途的骨侵袭治疗策略，但其临床应用受到缺乏肿瘤特异性靶向和骨组织渗透性差的限制。因此，有必要开发一种智能骨和肿瘤双靶向给药平台。我们设计了一种具有良好的骨靶向性和肿瘤靶向性以及免疫逃逸能力的双靶向性纳米仿生药物载体Asp 8 [H40-TPZ/IR780@（RBC-H）]，用于治疗颌骨恶性肿瘤。将这些纳米颗粒与头颈部鳞状细胞癌WSU-HN 6细胞（H）和红细胞（RBC）杂化膜包被，所述杂化膜由八天冬氨酸（Asp 8）的寡肽修饰。通过透射电镜观察了仿生纳米粒子的球形形貌和典型的核壳结构。这些纳米颗粒表现出与WSU-HN 6和RBC相同的表面蛋白。流式细胞术和共聚焦显微镜显示，与裸H40-PEG纳米颗粒相比，仿生纳米颗粒的吸收更大。纳米颗粒在体内的生物分布表明，它们主要定位于WSU-HN 6细胞的骨侵袭区域。此外，与其他TPZ或IR 780制剂相比，Asp 8 [H40-TPZ/IR 780 @（RBC-H）]纳米颗粒显示出有效的癌症生长抑制特性。Asp 8 [H40-TPZ/IR780@（RBC-H）]具有骨靶向、肿瘤归巢和免疫逃逸能力，是一种高效的多靶向药物载体，可实现骨侵袭过程中的精确抗癌治疗。在线版本包含补充材料，可通过10.1186/s12951-021-01088-9获得。
Jaw bones are the most common organs to be invaded by oral malignancies, such as oral squamous cell carcinoma (OSCC), because of their special anatomical relationship. Various serious complications, such as pathological fractures and bone pain can significantly decrease the quality of life or even survival outcomes for a patient. Although chemotherapy is a promising strategy for bone invasion treatment, its clinical applications are limited by the lack of tumor-specific targeting and poor permeability in bone tissue. Therefore, it is necessary to develop a smart bone and cancer dual targeting drug delivery platform. We designed a dual targeting nano-biomimetic drug delivery vehicle Asp8[H40-TPZ/IR780@(RBC-H)] that has excellent bone and cancer targeting as well as immune escape abilities to treat malignancies in jaw bones. These nanoparticles were camouflaged with a head and neck squamous cell carcinoma WSU-HN6 cell (H) and red blood cell (RBC) hybrid membrane, which were modified by an oligopeptide of eight aspartate acid (Asp8). The spherical morphology and typical core-shell structure of biomimetic nanoparticles were observed by transmission electron microscopy. These nanoparticles exhibited the same surface proteins as those of WSU-HN6 and RBC. Flow cytometry and confocal microscopy showed a greater uptake of the biomimetic nanoparticles when compared to bare H40-PEG nanoparticles. Biodistribution of the nanoparticles in vivo revealed that they were mainly localized in the area of bone invasion by WSU-HN6 cells. Moreover, the Asp8[H40-TPZ/IR780@(RBC-H)] nanoparticles exhibited effective cancer growth inhibition properties when compared to other TPZ or IR780 formulations. Asp8[H40-TPZ/IR780@(RBC-H)] has bone targeting, tumor-homing and immune escape abilities, therefore, it is an efficient multi-targeting drug delivery platform for achieving precise anti-cancer therapy during bone invasion. The online version contains supplementary material available at 10.1186/s12951-021-01088-9.
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DOI：
10.1073/pnas.1106634108
发表时间：
2011-07-05
影响因子：
11.1
作者：
Hu, Che-Ming J.;Zhang, Li;Zhang, Liangfang
通讯作者：
Zhang, Liangfang
基于 Boltorn H40 和聚乙二醇的阿仑膦酸盐共轭两亲性超支化聚合物，用于骨靶向药物输送
影响因子：
4.7
作者：
Chen, Hongying;Li, Guolin;Zhu, Xinyuan
通讯作者：
Zhu, Xinyuan
影响因子：
10.2
作者：
Lara, Pablo;Palma-Florez, Sujey;Kogan, Marcelo J.
通讯作者：
Kogan, Marcelo J.
影响因子：
10.2
作者：
Besic Gyenge E;Darphin X;Wirth A;Pieles U;Walt H;Bredell M;Maake C
通讯作者：
Maake C
影响因子：
7
作者：
Chen, Shih-Hong;Liu, Te-, I;Chiu, Hsin-Cheng
通讯作者：
Chiu, Hsin-Cheng