Prolymphangiogenic Effects of 9-cis Retinoic Acid Are Enhanced at Sites of Lymphatic Injury and Dependent on Treatment Duration in Experimental Postsurgical Lymphedema.
Prolymphangiogenic Effects of 9-cis Retinoic Acid Are Enhanced at Sites of Lymphatic Injury and Dependent on Treatment Duration in Experimental Postsurgical Lymphedema.
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9-顺式视黄酸的促淋巴管生成作用在淋巴损伤部位增强，并且取决于实验性术后淋巴水肿的治疗持续时间。
DOI：
10.1089/lrb.2021.0073
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发表时间：
2022
影响因子：
1.4
通讯作者：
Wong,AlexK
中科院分区：
文献类型：
--
作者：
Lee,GeneK;Perrault,DavidP;Bouz,Antoun;Pourmoussa,AustinJ;Yu,Roy;Kim,SooJung;Gardner,Daniel;Johnson,Maxwell;Park,SunYoung;Park,EunKyung;Seong,YoungJinN;Lee,Sunju;Jung,Eunson;Choi,Dongwon;Hong,Young-Kwon;Wong,AlexK
背景：接受实体瘤手术治疗的患者有因术中淋巴管损伤而发生继发性水肿的风险。受损的淋巴管不能充分再生，淋巴阻塞导致液体和蛋白质积聚在组织间隙中，结果形成慢性水肿。目前没有有效的药物可以降低发生水肿的风险或治疗既存水肿，治疗主要是姑息性的。本研究探讨了各种9-cisretinoic酸（9-cisRA）的剂量策略在减少术后水肿的疗效，通过利用一个完善的小鼠尾部水肿model.Methods和结果：短期治疗与9-cisRA没有表现出显着减少术后尾部体积，也没有改善淋巴清除。然而，与对照组相比，用9-cisRA长期处理导致总体尾体积、真皮厚度和表皮厚度降低，并且通过LYVE-1免疫染色评估功能性淋巴清除和淋巴管密度相关增加。这些影响被认为是在淋巴损伤的网站，没有显着的变化，观察到在未受伤的网站，如耳皮肤和diaphragm.Conclusions：鉴于报告的结果表明，9-顺式RA是一个有效的促进淋巴管生成和改善淋巴清除在淋巴损伤的网站，调查术后9-顺式RA管理的患者在高风险的发展中水肿可能会表现出积极的疗效和减少率的术后水肿。
Background:Patients undergoing surgical treatment for solid tumors are at risk for development of secondary lymphedema due to intraoperative lymphatic vessel injury. The damaged lymphatic vessels fail to adequately regenerate and lymphatic obstruction leads to fluid and protein accumulation in the interstitial space and chronic lymphedema develops as a result. There are currently no effective pharmacological agents that reduce the risk of developing lymphedema or treat pre-existing lymphedema, and management is largely palliative. The present study investigated the efficacy of various 9-cisretinoic acid (9-cisRA) dosing strategies in reducing postsurgical lymphedema by utilizing a well-established mouse tail lymphedema model.Methods and Results:Short-duration treatment with 9-cisRA did not demonstrate a significant reduction in postoperative tail volume, nor an improvement in lymphatic clearance. However, long-term treatment with 9-cisRA resulted in decreased overall tail volume, dermal thickness, and epidermal thickness, with an associated increase in functional lymphatic clearance and lymphatic vessel density, assessed by LYVE-1 immunostaining, compared with control. These effects were seen at the site of lymphatic injury, with no significant changes observed in uninjured sites such as ear skin and the diaphragm.Conclusions:Given the reported results indicating that 9-cisRA is a potent promoter of lymphangiogenesis and improved lymphatic clearance at sites of lymphatic injury, investigation of postoperative 9-cisRA administration to patients at high risk of developing lymphedema may demonstrate positive efficacy and reduced rates of postsurgical lymphedema.
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影响因子：
20.3
作者：
Uckun,FM;Gajl-Peczalska,KJ;Provisor,AJ;Heerema,NA
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DOI：
10.1200/jco.1987.5.7.1015
发表时间：
1987
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Dahl,GV;Rivera,GK;Look,AT;Hustu,HO;Kalwinsky,DK;Abromowitch,M;Mirro,J;Ochs,J;Murphy,SB;Dodge,RK
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Dodge,RK
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DOI：
--
发表时间：
1986
期刊：
影响因子：
--
作者：
S. Raimondi;DorothyL. Williams;T. Callihan;S. Peiper;G. Rivera;S. Murphy
通讯作者：
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