Roles for urothelium in normal and aberrant urinary tract development.
Roles for urothelium in normal and aberrant urinary tract development.
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DOI：
10.1038/s41585-020-0348-2
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发表时间：
2020-08
期刊：
影响因子：
--
通讯作者：
Becknell B
中科院分区：
文献类型：
--
作者：
Jackson AR;Ching CB;McHugh KM;Becknell B
先天性肾脏和泌尿道异常（CAKUT）是儿童慢性肾脏疾病和终末期肾脏疾病的主要原因。越来越多的证据表明尿路上皮在泌尿道发育和CAKUT的发生中起着关键作用。尿路上皮参与泌尿道的形成得到了CAKUT可能是尿路上皮发育异常的结果的证据的支持。新出现的证据表明，先天性尿路梗阻触发尿路上皮重塑，稳定梗阻的肾脏，限制肾损伤。最后，CAKUT患者泌尿系统的放射学检查结果和尿液生物标志物的诊断潜力可能有助于其对临床护理的贡献。
Congenital anomalies of the kidney and urinary tract (CAKUTs) represent the leading cause of chronic kidney disease and end-stage kidney disease in children. Increasing evidence points to critical roles for the urothelium in the developing urinary tract and in the genesis of CAKUTs. The involvement of the urothelium in patterning the urinary tract is supported by evidence that CAKUTs can arise as a result of abnormal urothelial development. Emerging evidence indicates that congenital urinary tract obstruction triggers urothelial remodelling that stabilizes the obstructed kidney and limits renal injury. Finally, the diagnostic potential of radiological findings and urinary biomarkers derived from the urothelium of patients with CAKUTs might aid their contribution to clinical care.
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