A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d.
A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d.
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DOI：
10.1084/jem.20061568
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发表时间：
2007-04-16
期刊：
影响因子：
--
通讯作者：
Bendelac A
中科院分区：
文献类型：
--
作者：
Sagiv Y;Bai L;Wei DG;Agami R;Savage PB;Teyton L;Bendelac A
Microsomal triglyceride transfer protein (MTP) is an endoplasmic reticulum (ER)–resident lipid transfer protein involved in the biosynthesis and lipid loading of apolipoprotein B. MTP was recently suggested to directly regulate the biosynthesis of the MHC I–like, lipid antigen presenting molecule CD1d, based on coprecipitation experiments and lipid loading assays. However, we found that the major impact of MTP deficiency occurred distal to the ER and Golgi compartments. Thus, although the rates of CD1d biosynthesis, glycosylation maturation, and internalization from the cell surface were preserved, the late but essential stage of recycling from lysosome to plasma membrane was profoundly impaired. Likewise, functional experiments indicated defects of CD1d-mediated lipid presentation in the lysosome but not in the secretory pathway. These intriguing findings suggest a novel, unexpected role of MTP at a late stage of CD1d trafficking in the lysosomal compartment.
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影响因子：
15.3
作者：
Benlagha, K;Weiss, A;Beavis, A;Teyton, L;Bendelac, A
通讯作者：
Bendelac, A
影响因子：
32.4
作者：
Jayawardena-Wolf, J;Benlagha, K;Bendelac, A
通讯作者：
Bendelac, A
影响因子：
4.4
作者：
Sagiv, Yuval;Hudspeth, Kelly;Bendelac, Albert
通讯作者：
Bendelac, Albert
影响因子：
4.4
作者：
Lawton, AP;Prigozy, TI;Kronenberg, M
通讯作者：
Kronenberg, M
影响因子：
30.5
作者：
Winau, F;Schwierzeck, V;Schaible, UE
通讯作者：
Schaible, UE